ArticleJournal of cancer research and clinical oncology2012
NDRG1/Cap43 overexpression in tumor tissues and serum from lung cancer patients.
Article in Journal of cancer research and clinical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Insight into the Regulation of NDRG1 Expression.International journal of molecular sciences · 2025Review
- Prognostic biomarker discovery based on proteome landscape of Chinese lung adenocarcinoma.Clinical proteomics · 2024Article
- Upregulation of NDRG1 predicts poor outcome and facilitates disease progression by influencing the EMT process in bladder cancer.Scientific reports · 2019Article
- MORC2 promotes development of an aggressive colorectal cancer phenotype through inhibition of NDRG1.Cancer science · 2019Article
- A 16-gene expression signature to distinguish stage I from stage II lung squamous carcinoma.International journal of molecular medicine · 2018Article
- NDRG1 Controls Gastric Cancer Migration and Invasion through Regulating MMP-9.Pathology oncology research : POR · 2016Article
- NDRG1 overexpression promotes the progression of esophageal squamous cell carcinoma through modulating Wnt signaling pathway.Cancer biology & therapy · 2016Article
- An exact algorithm for finding cancer driver somatic genome alterations: the weighted mutually exclusive maximum set cover problem.Algorithms for molecular biology : AMB · 2016Article
- NDRG1 expression is related to the progression and prognosis of gastric cancer patients through modulating proliferation, invasion and cell cycle of gastric cancer cells.Molecular biology reports · 2014Article
- Suppressing N-Myc downstream regulated gene 1 reactivates senescence signaling and inhibits tumor growth in hepatocellular carcinoma.Carcinogenesis · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe N-myc downstream regulated gene 1 (NDRG1)/Cap43 is overexpressed in multiple cancer types, including lung cancer. In this study, we investigated the expression of NDRG1/Cap43 in lung cancer tissues and in serum from 90 lung cancer patients and 60 healthy controls. MATERIALS AND
methodsNinety patients with pathologically confirmed primary lung cancer who underwent surgical resections were recruited for the study. From resected sections, we dissected lung tumor tissues and adjacent noncancerous tissues that were used as controls and collected patient sera for NDRG1/Cap43 expression levels. Immunohistochemical staining was applied to detect NDRG1/Cap43-positive tumor cells, and real-time quantitative-PCR (RT-PCR) was used to determine mRNA transcript levels of NDRG1/Cap43 in lung cancer tissues. Serum levels of NDRG1/Cap43 were measured by Enzyme-linked immunosorbent assays (ELISA). Data comparison between two groups was performed by independent two sample test, and comparison between more than two groups was applied by the analysis of variance (ANOVA) test.
resultsCompared with adjacent normal tissues, lung cancer tissues had significantly increased expression of NDRG1/Cap43 (P < 0.05). Lung adenocarcinomas also had significantly higher NDRG1/Cap43 levels than lung squamous carcinomas (P < 0.01). RT-PCR analysis showed significantly higher levels of NDRG1/Cap43 mRNA transcripts in lung cancer tissues compared with matched adjacent noncancerous tissues (P < 0.05). mRNA expression of NDRG1/Cap43 was associated with the histological pattern of lung cancer. ELISA analysis for serum NDRG1/Cap43 levels revealed significantly higher levels in lung cancer patients (358.56 ± 233.82 ng/mL) compared with healthy controls (28.83 ± 10.51 ng/mL, P < 0.001).
conclusionsNDRG1/Cap43 overexpression may be of predictive value in determining the prognosis of lung cancer patients.
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