ArticleMicron (Oxford, England : 1993)2012
Increased imaging speed and force sensitivity for bio-applications with small cantilevers using a conventional AFM setup.
Article in Micron (Oxford, England : 1993), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Enhancing higher-order modal response in multifrequency atomic force microscopy with a coupled cantilever system.Beilstein journal of nanotechnology · 2024Article
- Article
- Review: Cantilever-Based Sensors for High Speed Atomic Force Microscopy.Sensors (Basel, Switzerland) · 2020Review
- Integration of sharp silicon nitride tips into high-speed SU8 cantilevers in a batch fabrication process.Beilstein journal of nanotechnology · 2019Article
- Modification of the AFM Sensor by a Precisely Regulated Air Stream to Increase Imaging Speed and Accuracy in the Contact Mode.Sensors (Basel, Switzerland) · 2018Article
- Feeling for Filaments: Quantification of the Cortical Actin Web in Live Vascular Endothelium.Biophysical journal · 2015Article
- Atomic force microscopy: a multifaceted tool to study membrane proteins and their interactions with ligands.Biochimica et biophysica acta · 2014Review
- Single cell spectroscopy: noninvasive measures of small-scale structure and function.Methods (San Diego, Calif.) · 2013Review
Corrections and comments
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Authors and funding
10 authors.
Funding
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Abstract
In this study, we demonstrate the increased performance in speed and sensitivity achieved by the use of small AFM cantilevers on a standard AFM system. For this, small rectangular silicon oxynitride cantilevers were utilized to arrive at faster atomic force microscopy (AFM) imaging times and more sensitive molecular recognition force spectroscopy (MRFS) experiments. The cantilevers we used had lengths between 13 and 46 μm, a width of about 11 μm, and a thickness between 150 and 600 nm. They were coated with chromium and gold on the backside for a better laser reflection. We characterized these small cantilevers through their frequency spectrum and with electron microscopy. Due to their small size and high resonance frequency we were able to increase the imaging speed by a factor of 10 without any loss in resolution for images from several μm scansize down to the nanometer scale. This was shown on bacterial surface layers (s-layer) with tapping mode under aqueous, near physiological conditions and on nuclear membranes in contact mode in ambient environment. In addition, we showed that single molecular forces can be measured with an up to 5 times higher force sensitivity in comparison to conventional cantilevers with similar spring constants.
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