ArticlePain2012
Functional abdominal pain patient subtypes in childhood predict functional gastrointestinal disorders with chronic pain and psychiatric comorbidities in adolescence and adulthood.
Article in Pain, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
117 citing papers in PubMed, 4 syntheses or guidelines pooled it, 222 citations in OpenAlex.
- Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children and adolescents.The Cochrane database of systematic reviews · 2019Pooled it
- Psychological therapies for the management of chronic and recurrent pain in children and adolescents.The Cochrane database of systematic reviews · 2018Pooled it
- Pooled it
- Pooled it
- The Role of Psychosocial Risk Status in Relation to Outcomes Following Cognitive Behavioral Therapy for Youth with Abdominal Pain-Related Disorders of Gut-Brain Interaction.Journal of clinical psychology in medical settings · 2026Trial
- Trial
- Does Quantitative Sensory Testing Improve Prediction of Chronic Pain Trajectories? A Longitudinal Study of Youth With Functional Abdominal Pain Participating in a Randomized Controlled Trial of Cognitive Behavioral Treatment.The Clinical journal of pain · 2021Trial
- Development of the Aim to Decrease Anxiety and Pain Treatment for Pediatric Functional Abdominal Pain Disorders.Journal of pediatric gastroenterology and nutrition · 2018Trial
- Risk Categorization Predicts Disability in Pain-associated Functional Gastrointestinal Disorders After 6 Months.Journal of pediatric gastroenterology and nutrition · 2017Trial
- Cognitive mediators of treatment outcomes in pediatric functional abdominal pain.The Clinical journal of pain · 2014Trial
- Claudin-3 as a marker of intestinal permeability and its relation to inflammatory status in adolescents with functional gastrointestinal disorders.Pediatric research · 2026Article
- Sleep, Stress, Circadian Rhythm, and Diet in Pediatric Disorders of Gut-Brain Interaction: A Narrative Review.Nutrients · 2026Review
- Prevalence and competing risk of psychiatric comorbidities in chronic low back pain by age group.Pain reports · 2026Article
- Identifying Prognostic Factors Implicated in Chronic Functional Abdominal Pain in Children: A Systematic Review.Gastroenterology research · 2026Review
- The Mediating Role of Pain Catastrophizing in Functioning and Mental Health for Youth With Pain-predominant Disorders of Gut-Brain Interaction.Journal of clinical gastroenterology · 2026Article
- The true experts: codeveloping a preventive psychological intervention for postsurgical pain with patients and caregivers.Pain reports · 2026Article
- Article
- Why sleep matters in chronic pain: evidence across the lifespan.EBioMedicine · 2026Review
- Dissemination of Pediatric Chronic Pain Research: Views from Patients, Caregivers, and Healthcare Professionals.Journal of pain research · 2026Article
- High impact chronic pain in children: exploration of associated characteristics and clinical factors in children and parents.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
57 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Although pediatric functional abdominal pain (FAP) has been linked to abdominal pain later in life, childhood predictors of long-term outcomes have not been identified. This study evaluated whether distinct FAP profiles based on patterns of pain and adaptation in childhood could be identified and whether these profiles predicted differences in clinical outcomes and central sensitization (wind-up) on average 9years later. In 843 pediatric FAP patients, cluster analysis was used to identify subgroups at initial FAP evaluation based on profiles of pain severity, gastrointestinal (GI) and non-GI symptoms, pain threat appraisal, pain coping efficacy, catastrophizing, negative affect, and activity impairment. Three profiles were identified: high pain dysfunctional, high pain adaptive, and low pain adaptive. Logistic regression analyses controlling for age and sex showed that, compared with pediatric patients with the low pain adaptive profile, those with the high pain dysfunctional profile were significantly more likely at long-term follow-up to meet criteria for pain-related functional gastrointestinal disorder (FGID) (odds ratio: 3.45, confidence interval: 1.95 to 6.11), FGID with comorbid nonabdominal chronic pain (odds ratio: 2.6, confidence interval: 1.45 to 4.66), and FGID with comorbid anxiety or depressive psychiatric disorder (odds ratio: 2.84, confidence interval: 1.35 to 6.00). Pediatric patients with the high pain adaptive profile had baseline pain severity comparable to that of the high pain dysfunctional profile, but had outcomes as favorable as the low pain adaptive profile. In laboratory pain testing at follow-up, high pain dysfunctional patients showed significantly greater thermal wind-up than low pain adaptive patients, suggesting that a subgroup of FAP patients has outcomes consistent with widespread effects of heightened central sensitization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.