ArticleExperimental eye research2012
Layer-specific blood-flow MRI of retinitis pigmentosa in RCS rats.
Article in Experimental eye research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- Optical coherence tomography angiography in Retinitis Pigmentosa.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Measuring spatial visual loss in rats by retinotopic mapping of the superior colliculus using a novel multi-electrode array technique.Journal of neuroscience methods · 2024Article
- Improved MRI methods to quantify retinal and choroidal blood flow applied to a model of glaucoma.Frontiers in ophthalmology · 2024Article
- Investigation of Structural Alterations in Inherited Retinal Diseases: A Quantitative SD-OCT-Analysis of Retinal Layer Thicknesses in Light of Underlying Genetic Mutations.International journal of molecular sciences · 2022Article
- Advanced Diffusion MRI of the Visual System in Glaucoma: From Experimental Animal Models to Humans.Biology · 2022Review
- Diabetic mice have retinal and choroidal blood flow deficits and electroretinogram deficits with impaired responses to hypercapnia.PloS one · 2021Article
- Co-grafts of Human Embryonic Stem Cell Derived Retina Organoids and Retinal Pigment Epithelium for Retinal Reconstruction in Immunodeficient Retinal Degenerate Royal College of Surgeons Rats.Frontiers in neuroscience · 2021Article
- Effect of Dual Endothelin Receptor Antagonist on a Retinal Degeneration Animal Model by Regulating Choroidal Microvascular Morphology.Journal of ophthalmology · 2021Article
- Quantification of Macular Microvascular Changes in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
- Comparative Optical Coherence Tomography Angiography of Wild-Type and rd10 Mouse Retinas.Translational vision science & technology · 2018Article
- Quantitative progression of retinitis pigmentosa by optical coherence tomography angiography.Scientific reports · 2018Article
- High-resolution Imaging in Male Germ Cell-Associated Kinase (MAK)-related Retinal Degeneration.American journal of ophthalmology · 2018Article
- Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models.Stem cells international · 2017Review
- Dynamic contrast optical coherence tomography images transit time and quantifies microvascular plasma volume and flow in the retina and choriocapillaris.Biomedical optics express · 2016Article
- Application of Arterial Spin Labelling in the Assessment of Ocular Tissues.BioMed research international · 2016Review
- The potential utility of non-invasive imaging to monitor restoration of bladder structure and function following subtotal cystectomy (STC).BMC urology · 2015Article
- Choroidal blood flow decreases with age: an MRI study.Current eye research · 2014Article
- Comparison of retinal and cerebral blood flow between continuous arterial spin labeling MRI and fluorescent microsphere techniques.Journal of magnetic resonance imaging : JMRI · 2014Article
- Magnetic resonance imaging of the retina: from mice to men.Magnetic resonance in medicine · 2014Review
- Association of retinal vessel attenuation with visual function in eyes with retinitis pigmentosa.Clinical ophthalmology (Auckland, N.Z.) · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The Royal College of Surgeons (RCS) rat is an established animal model of retinitis pigmentosa, a family of inherited retinal diseases which starts with loss of peripheral vision and progresses to eventual blindness. Blood flow (BF), an important physiological parameter, is intricately coupled to metabolic function under normal physiological conditions and is perturbed in many neurological and retinal diseases. This study reports non-invasive high-resolution MRI (44 × 44 × 600 μm) to image quantitative retinal and choroidal BF and layer-specific retinal thicknesses in RCS rat retinas at different stages of retinal degeneration compared with age-matched controls. The unique ability to separate retinal and choroidal BF was made possible by the depth-resolved MRI technique. RBF decreased with progressive retinal degeneration, but ChBF did not change in RCS rats up to post-natal day 90. We concluded that choroidal and retinal circulations have different susceptibility to progressive retinal degeneration in RCS rats. Layer-specific retinal thickness became progressively thinner and was corroborated by histological analysis in the same animals. MRI can detect progressive anatomical and BF changes during retinal degeneration with laminar resolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.