ReviewTrends in endocrinology and metabolism: TEM2012
Role of intramyocelluar lipids in human health.
Review in Trends in endocrinology and metabolism: TEM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
141 citing papers in PubMed, 1 synthesis or guideline pooled it, 243 citations in OpenAlex.
- Fatty infiltration in the thigh muscles in knee osteoarthritis: a systematic review and meta-analysis.Rheumatology international · 2019Pooled it
- Comparison of intramyocellular lipid metabolism in patients with diabetes and male athletes.Nature communications · 2024Trial
- Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle.Diabetologia · 2022Trial
- Trial
- A periodized training attenuates thigh intermuscular fat and improves muscle quality in patients with knee osteoarthritis: results from a randomized controlled trial.Clinical rheumatology · 2020Trial
- Plasma lipid profiling of tissue-specific insulin resistance in human obesity.International journal of obesity (2005) · 2019Trial
- Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans.Diabetologia · 2016Trial
- Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans.Diabetologia · 2016Trial
- Altered Skeletal Muscle Fatty Acid Handling in Subjects with Impaired Glucose Tolerance as Compared to Impaired Fasting Glucose.Nutrients · 2016Trial
- Trial
- Modulation of the lipidomic profile due to a lipid challenge and fitness level: a postprandial study.Lipids in health and disease · 2015Trial
- Defects in mitochondrial efficiency and H2O2 emissions in obese women are restored to a lean phenotype with aerobic exercise training.Diabetes · 2015Trial
- Triglyceride-related metabolic indices and low relative muscle mass: a cross-sectional analysis of SMILE and NHANES.Endocrine · 2026Article
- Myosteatosis and Dyslipidemia: Linking Muscle Quality to Cardiometabolic Risk.Journal of lipid and atherosclerosis · 2026Review
- Review
- Muscle movement and metabolism: exercise and skeletal muscle as mediators of health-a report from the 26th Annual Harvard Nutrition Obesity Symposium, 2025.The American journal of clinical nutrition · 2026Article
- Fibre morphology, intramyocellular lipid content and 3D capillary architecture in human postural, respiratory and locomotor muscles in type 2 diabetes mellitus.Histochemistry and cell biology · 2026Article
- Deep learning-based framework for comprehensive quantification of thigh and calf muscles and adipose tissues from MRI.Magma (New York, N.Y.) · 2026Article
- Automated deep-learning quantification of intramuscular fat in lumbar spine muscles on Dixon MRI: validation and normative reference values from 173 healthy adults.BMC medical imaging · 2026Article
- Reference Methods for Measuring Skeletal Muscle Mass: A Critical Perspective.Journal of cachexia, sarcopenia and muscle · 2026Review
81 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Intramyocellular lipid (IMCL) is predominantly stored as intramuscular triglyceride (IMTG) in lipid droplets and is utilized as metabolic fuel during physical exercise. IMTG is also implicated in muscle insulin resistance (IR) in type 2 diabetes. However, it has become apparent that lipid moieties such as ceramide and diacylglycerol are the likely culprits of IR. This article reviews current knowledge of IMCL-mediated IR and important areas of investigation, including myocellular lipid transport and lipid droplet proteins. Several crucial questions remain unanswered, such as the identity of specific ceramide and diacylglycerol species that mediate IR in human muscle and their subcellular location. Quantitative lipidomics and proteomics of targeted subcellular organelles will help to better define the mechanisms underlying pathological IMCL accumulation and IR.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.