ArticleThe Journal of surgical research2012
Rapid screening of cancer margins in tissue with multimodal confocal microscopy.
Article in The Journal of surgical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Accuracy of the LaserSAFE technique for detecting positive surgical margins during robot-assisted radical prostatectomy: blind assessment and inter-rater agreement analysis.Histopathology · 2025Trial
- Intraoperative margin assessment using fluorescence confocal microscopy during robot-assisted radical prostatectomy: a first experience.BJU international · 2026Observational
- H&E Style Translation Using CycleGAN for Deep Ultraviolet-Excitation Fluorescence Images of Pancreatic Endoscopic Ultrasound-Fine Needle Aspiration/Biopsy Toward Slide-Free Rapid Pathology.Acta histochemica et cytochemica · 2025Article
- Single color digital H&E staining with In-and-Out Net.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2024Article
- Article
- Virtual Staining of Nonfixed Tissue Histology.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2024Review
- Intraoperative imaging in pathology-assisted surgery.Nature biomedical engineering · 2022Review
- Slide Over: Advances in Slide-Free Optical Microscopy as Drivers of Diagnostic Pathology.The American journal of pathology · 2022Review
- Fast hybrid optomechanical scanning photoacoustic remote sensing microscopy for virtual histology.Biomedical optics express · 2022Article
- Ex vivo confocal microscopy performs real-time assessment of renal biopsy in non-neoplastic diseases.Journal of nephrology · 2021Article
- Clinically Compatible Fluorescence Microscopy Based on Moxifloxacin Antibiotic.Advances in experimental medicine and biology · 2021Article
- Ex Vivo Microscopy: A Promising Next-Generation Digital Microscopy Tool for Surgical Pathology Practice.Archives of pathology & laboratory medicine · 2019Review
- Rapid tissue histology using multichannel confocal fluorescence microscopy with focus tracking.Quantitative imaging in medicine and surgery · 2018Article
- Line scanning, stage scanning confocal microscope (LSSSCM).Biomedical optics express · 2017Article
- Implementation of fluorescence confocal mosaicking microscopy by "early adopter" Mohs surgeons and dermatologists: recent progress.Journal of biomedical optics · 2017Article
- Use of Digitally Stained Multimodal Confocal Mosaic Images to Screen for Nonmelanoma Skin Cancer.JAMA dermatology · 2016Article
- In Vivo and Ex Vivo Confocal Microscopy for Dermatologic and Mohs Surgeons.Dermatologic clinics · 2016Review
- In vivo evaluation of adipose- and muscle-derived stem cells as a treatment for nonhealing diabetic wounds using multimodal microscopy.Journal of biomedical optics · 2016Article
- Rapid staining and imaging of subnuclear features to differentiate between malignant and benign breast tissues at a point-of-care setting.Journal of cancer research and clinical oncology · 2016Article
- DRAQ5 and Eosin ('D&E') as an Analog to Hematoxylin and Eosin for Rapid Fluorescence Histology of Fresh Tissues.PloS one · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundComplete and accurate excision of cancer is guided by the examination of histopathology. However, preparation of histopathology is labor intensive and slow, leading to insufficient sampling of tissue and incomplete and/or inaccurate excision of margins. We demonstrate the potential utility of multimodal confocal mosaicing microscopy for rapid screening of cancer margins, directly in fresh surgical excisions, without the need for conventional embedding, sectioning, or processing. MATERIALS AND
methodsA multimodal confocal mosaicing microscope was developed to image basal cell carcinoma margins in surgical skin excisions, with the resolution that shows nuclear detail. Multimodal contrast is with fluorescence for imaging nuclei and reflectance for cellular cytoplasm and dermal collagen. Thirty-five excisions of basal cell carcinomas from Mohs surgery were imaged, and the mosaics analyzed by comparison with the corresponding frozen pathology.
resultsConfocal mosaics are produced in about 9 min, displaying tissue in fields of view of 12 mm with ×2 magnification. A digital staining algorithm transforms black and white contrast to purple and pink, which simulates the appearance of standard histopathology. Mosaicing enables rapid digital screening, which mimics the examination of histopathology.
conclusionsMultimodal confocal mosaicing microscopy offers a technology platform to potentially enable real-time pathology at the bedside. The imaging may serve as an adjunct to conventional histopathology to expedite screening of margins and guide surgery toward more complete and accurate excision of cancer.
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Registered trials
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