ArticlePloS one2012
Transcriptional responses of resistant and susceptible fish clones to the bacterial pathogen Flavobacterium psychrophilum.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Article
- Remarkable heterogeneity revealed in the genetic architecture of resistance to a key bacterial pathogen in two commercial rainbow trout populations.BMC genomics · 2025Article
- Article
- Understanding the Pathogenesis of Red Mark Syndrome in Rainbow Trout (Animals : an open access journal from MDPI · 2023Article
- Effect of glyphosate, its metabolite AMPA, and the glyphosate formulation RoundupFrontiers in microbiology · 2023Article
- Plasma proteomic profiling of bacterial cold water disease-resistant and -susceptible rainbow trout lines and biomarker discovery.Frontiers in immunology · 2023Article
- Early innate immune responses in European sea bass (Frontiers in immunology · 2023Article
- Two functionally distinct heme/iron transport systems are virulence determinants of the fish pathogenVirulence · 2022Article
- Exposure to 17α-Ethinylestradiol Results in Differential Susceptibility of Largemouth Bass (Environmental science & technology · 2022Article
- Dual resistance to Flavobacterium psychrophilum and Myxobolus cerebralis in rainbow trout (Oncorhynchus mykiss, Walbaum).Journal of fish diseases · 2022Article
- Genomics and transcriptomics reveal new molecular mechanism of vibriosis resistance in fish.Frontiers in immunology · 2022Article
- A BCWD-Resistant line of rainbow trout is less sensitive to cortisol implant-induced changes in IgM response as compared to a susceptible (control) line.Developmental and comparative immunology · 2021Article
- Evolution of the IRF Family in Salmonids.Genes · 2021Article
- Production and verification of the first Atlantic salmon (Salmo salar L.) clonal lines.BMC genetics · 2020Article
- Combining Multiple Approaches and Models to Dissect the Genetic Architecture of Resistance to Infections in Fish.Frontiers in genetics · 2020Review
- Comparative Genomic Analysis of Three Salmonid Species Identifies Functional Candidate Genes Involved in Resistance to the Intracellular BacteriumFrontiers in genetics · 2019Article
- Quantitative trait loci for resistance to Flavobacterium psychrophilum in rainbow trout: effect of the mode of infection and evidence of epistatic interactions.Genetics, selection, evolution : GSE · 2018Article
- Capture severity, infectious disease processes and sex influence post-release mortality of sockeye salmon bycatch.Conservation physiology · 2017Article
- Transcriptional response of Atlantic salmon families to Piscirickettsia salmonis infection highlights the relevance of the iron-deprivation defence system.BMC genomics · 2015Article
- Analysis of immune-related ESTs and differential expression analysis of few important genes in lines of rohu (Labeo rohita) selected for resistance and susceptibility to Aeromonas hydrophila infection.Molecular biology reports · 2014Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flavobacterium psychrophilum is a bacterial species that represents one of the most important pathogens for aquaculture worldwide, especially for salmonids. To gain insights into the genetic basis of the natural resistance to F. psychrophilum, we selected homozygous clones of rainbow trout with contrasted susceptibility to the infection. We compared the transcriptional response to the bacteria in the pronephros of a susceptible and a resistant line by micro-array analysis five days after infection. While the basal transcriptome of healthy fish was significantly different in the resistant and susceptible lines, the transcriptome modifications induced by the bacteria involved essentially the same genes and pathways. The response to F. psychrophilum involved antimicrobial peptides, complement, and a number of enzymes and chemokines. The matrix metalloproteases mmp9 and mmp13 were among the most highly induced genes in both genetic backgrounds. Key genes of both pro- and anti-inflammatory response such as IL1 and IL10, were up-regulated with a greater magnitude in susceptible animals where the bacterial load was also much higher. While higher resistance to F. psychrophilum does not seem to be based on extensive differences in the orientation of the immune response, several genes including complement C3 showed stronger induction in the resistant fish. They may be important for the variation of susceptibility to the infection.
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