ArticlePloS one2012
Expression of UV-sensitive parapinopsin in the iguana parietal eyes and its implication in UV-sensitivity in vertebrate pineal-related organs.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 80 citations in OpenAlex.
- From pineal photoreception to optogenetics: functional colour opponency based on a pineal bistable opsin.Eye and vision (London, England) · 2026Review
- Wavelength-dependent sleep state manipulation using light pulses in Pogona vitticeps.Communications biology · 2026Article
- Adaptive Emergence Patterns of Spot-Tailed Earless Lizards: Influence of UV Light and Temperature on Diel Activity.Ecology and evolution · 2025Article
- Evolution of Pineal Nonvisual Opsins in Lizards and the Tuatara and Identification of Lepidopsin: A New Opsin Gene.Genome biology and evolution · 2025Article
- Light intensity-dependent arrestin switching for inactivation of a light-sensitive GPCR, bistable opsin.iScience · 2025Article
- Functional characterization of four opsins and two G alpha subtypes co-expressed in the molluscan rhabdomeric photoreceptor.BMC biology · 2023Article
- Optogenetic manipulation of Gq- and Gi/o-coupled receptor signaling in neurons and heart muscle cells.eLife · 2023Article
- High-performance optical control of GPCR signaling by bistable animal opsins MosOpn3 and LamPP in a molecular property-dependent manner.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Expression of a homologue of a vertebrate non-visual opsin Opn3 in the insect photoreceptors.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Insights into the evolutionary origin of the pineal color discrimination mechanism from the river lamprey.BMC biology · 2021Article
- Functional identification of an opsin kinase underlying inactivation of the pineal bistable opsin parapinopsin in zebrafish.Zoological letters · 2021Article
- Optogenetic Potentials of Diverse Animal Opsins: Parapinopsin, Peropsin, LWS Bistable Opsin.Advances in experimental medicine and biology · 2021Review
- Type II Opsins in the Eye, the Pineal Complex and the Skin ofFrontiers in neuroanatomy · 2021Review
- The non-visual opsins expressed in deep brain neurons projecting to the retina in lampreys.Scientific reports · 2020Article
- Evolutionary history of teleost intron-containing and intron-less rhodopsin genes.Scientific reports · 2019Article
- Color opponency with a single kind of bistable opsin in the zebrafish pineal organ.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Pinopsin evolved as the ancestral dim-light visual opsin in vertebrates.Communications biology · 2018Article
- Signaling and Gene Regulatory Networks in Mammalian Lens Development.Trends in genetics : TIG · 2017Review
- Chromatic clocks: Color opponency in non-image-forming visual function.Neuroscience and biobehavioral reviews · 2017Review
- Spontaneous magnetic alignment behaviour in free-living lizards.Die Naturwissenschaften · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pineal-related organs of lower vertebrates have the ability to discriminate different wavelengths of light. This wavelength discrimination is achieved through antagonistic light responses to UV or blue and visible light. Previously, we demonstrated that parapinopsin underlies the UV reception in the lamprey pineal organ and identified parapinopsin genes in teleosts and frogs of which the pineal-related organs were reported to discriminate light. In this study, we report the first identification of parapinopsin in the reptile lineage and show its expression in the parietal eye of the green iguana. Spectroscopic analysis revealed that iguana parapinopsin is a UV-sensitive pigment, similar to lamprey parapinopsin. Interestingly, immunohistochemical analyses using antibodies specific to parapinopsin and parietopsin, a parietal eye green-sensitive pigment, revealed that parapinopsin and parietopsin are colocalized in the outer segments of the parietal eye photoreceptor cells in iguanas. These results strongly suggest that parapinopsin underlies the wavelength discrimination involving UV reception in the iguana parietal eye. The current findings support the idea that parapinopsin is a common photopigment underlying the UV-sensitivity in wavelength discrimination of the pineal-related organs found from lampreys to reptiles.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.