ArticlePloS one2012
Pericardial patch angioplasty heals via an Ephrin-B2 and CD34 positive cell mediated mechanism.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Cardiovascular patches applied in congenital cardiac surgery: Current materials and prospects.Bioengineering & translational medicine · 2025Review
- Extracellular Matrix Patches for Endarterectomy Repair.Frontiers in cardiovascular medicine · 2021Article
- Molecular identity of arteries, veins, and lymphatics.Journal of vascular surgery · 2019Review
- Atorvastatin regulates pericardial patch healing via the microRNA140-ADAM10-ephrinB2 pathway.American journal of translational research · 2018Article
- Transforming Growth Factor-β1 Inhibits Pseudoaneurysm Formation After Aortic Patch Angioplasty.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Polyester vascular patches acquire arterial or venous identity depending on their environment.Journal of biomedical materials research. Part A · 2017Article
- Patch Angioplasty in the Rat Aorta or Inferior Vena Cava.Journal of visualized experiments : JoVE · 2017Article
- Covalent modification of pericardial patches for sustained rapamycin delivery inhibits venous neointimal hyperplasia.Scientific reports · 2017Article
- Pericardial patch venoplasty heals via attraction of venous progenitor cells.Physiological reports · 2016Article
- Pretreatment of pericardial patches with antibiotics does not alter patch healing in vivo.Journal of vascular surgery · 2016Article
- An in vivo study of a gold nanocomposite biomaterial for vascular repair.Biomaterials · 2015Article
- Autologous tissue patches acquire vascular identity depending on the environment.Vascular investigation and therapyArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivePericardial patches are commonly used in vascular surgery to close arteriotomies. The mechanism of early healing after patch implantation is still not well defined. We used a rat aortic patch model to assess pericardial patch healing and examined Ephrin-B2, a marker of arterial identity, expression within the post-implantation patch. We also determined whether endothelial progenitor cells (EPC) are associated with early patch healing in the arterial environment.
methodsWistar rats (200-250 grams) underwent infrarenal aortic arteriotomy and then closure via bovine or porcine pericardial patch angioplasty. Control groups included subcutaneously implanted patches. Patches were harvested at 0-30 days and analyzed by histology, immunohistochemistry, immunofluorescence and Western blot as well as quantitative PCR.
resultsPrior to implantation, pericardial patches are largely composed of collagen and are acellular. Following arterial implantation, increasing numbers of CD68-positive cells as well as Ephrin-B2 and CD34 dual-positive cells are found within both bovine and porcine pericardial patches, whereas the infiltrating cells are negative for vWF and α-actin. Porcine patches have a luminal monolayer of cells at day 7, compared to bovine patches that have fewer luminal cells. Subcutaneously implanted patches do not attract Ephrin-B2/CD34-positive cells. By day 30, both bovine and porcine pericardial patches develop a neointima that contains Ephrin-B2, CD34, and VEGFR2-positive cells.
conclusionBoth CD68-positive and Ephrin-B2 and CD34 dual-positive cells infiltrate the pericardial patch early after implantation. Arteriotomy closure via pericardial patch angioplasty shows patch adaptation to the arterial environment that may involve a foreign body response as well as localization of EPC. Arterial remodeling of pericardial patches support endothelialization and may represent a paradigm of healing of scaffolds used for tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.