ArticlePloS one2012
Host genes related to paneth cells and xenobiotic metabolism are associated with shifts in human ileum-associated microbial composition.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- ATG16L1 rs2241880/T300A increases susceptibility to perianal Crohn's disease: An updated meta-analysis on inflammatory bowel disease risk and clinical outcomes.United European gastroenterology journal · 2024Pooled it
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- Berberine inhibits IFN-γ signaling pathway in DSS-induced ulcerative colitis.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- Expression of Cytokine-Coding GenesGenes · 2021Article
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- Impact of preoperative antibiotics and other variables on integrated microbiome-host transcriptomic data generated from colorectal cancer resections.World journal of gastroenterology · 2021Article
- Influence of Crohn's disease related polymorphisms in innate immune function on ileal microbiome.PloS one · 2019Article
- Identification of Candidate Adherent-Invasive E. coli Signature Transcripts by Genomic/Transcriptomic Analysis.PloS one · 2015Article
- Altered Interactions between the Gut Microbiome and Colonic Mucosa Precede Polyposis in APCMin/+ Mice.PloS one · 2015Article
- The genetic predisposition and the interplay of host genetics and gut microbiome in Crohn disease.Clinics in laboratory medicine · 2014Review
- Identifying candidate genes for discrimination of ulcerative colitis and Crohn's disease.Molecular biology reports · 2014Article
- Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.The Journal of clinical investigation · 2014Article
- Clinical implications of shared genetics and pathogenesis in autoimmune diseases.Nature reviews. Endocrinology · 2013Review
- Paneth cells and necrotizing enterocolitis: a novel hypothesis for disease pathogenesis.Neonatology · 2013Review
- A modular organization of the human intestinal mucosal microbiota and its association with inflammatory bowel disease.PloS one · 2013Article
- Parallel comparison of Illumina RNA-Seq and Affymetrix microarray platforms on transcriptomic profiles generated from 5-aza-deoxy-cytidine treated HT-29 colon cancer cells and simulated datasets.BMC bioinformatics · 2013Article
- The Human Microbiome Project: a community resource for the healthy human microbiome.PLoS biology · 2012Article
- An ileal Crohn's disease gene signature based on whole human genome expression profiles of disease unaffected ileal mucosal biopsies.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
The aim of this study was to integrate human clinical, genotype, mRNA microarray and 16 S rRNA sequence data collected on 84 subjects with ileal Crohn's disease, ulcerative colitis or control patients without inflammatory bowel diseases in order to interrogate how host-microbial interactions are perturbed in inflammatory bowel diseases (IBD). Ex-vivo ileal mucosal biopsies were collected from the disease unaffected proximal margin of the ileum resected from patients who were undergoing initial intestinal surgery. Both RNA and DNA were extracted from the mucosal biopsy samples. Patients were genotyped for the three major NOD2 variants (Leufs1007, R702W, and G908R) and the ATG16L1T300A variant. Whole human genome mRNA expression profiles were generated using Agilent microarrays. Microbial composition profiles were determined by 454 pyrosequencing of the V3-V5 hypervariable region of the bacterial 16 S rRNA gene. The results of permutation based multivariate analysis of variance and covariance (MANCOVA) support the hypothesis that host mucosal Paneth cell and xenobiotic metabolism genes play an important role in host microbial interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.