ArticleJournal of clinical medicine research2012
The impact of thiamine treatment in the diabetes mellitus.
Article in Journal of clinical medicine research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05663164 (Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species (ROS) in Perioperative Stress Response
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- A Systematic Review of Thiamine Supplementation in Improving Diabetes and Its Related Cardiovascular Dysfunction.International journal of molecular sciences · 2025Pooled it
- Thiamine transporter 2 and Janus kinase 2 inhibitor, fedratinib suppresses thermogenic activation of human neck area-derived adipocytes.Frontiers in endocrinology · 2026Article
- Hidden Hunger in Pediatric Obesity: Redefining Malnutrition Through Macronutrient Quality and Micronutrient Deficiency.Nutrients · 2025Review
- Association between dietary vitamin B1 intake and stroke risk in older patients: a retrospective cross-sectional study.BMC neurology · 2025Article
- Association between vitamin B1 intake and hyperuricemia in adults.Scientific reports · 2024Article
- Applying Network Pharmacology and Molecular Docking in the Screening for Molecular Mechanisms of Ampalaya (Acta medica Philippina · 2024Article
- Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies.Life (Basel, Switzerland) · 2023Review
- Modulatory effect of caffeic acid in alleviating diabetes and associated complications.World journal of diabetes · 2023Review
- Effects of Interaction betweenNutrients · 2023Article
- The Roles of Vitamins in Diabetic Retinopathy: A Narrative Review.Journal of clinical medicine · 2022Review
- The role of pancreas to improve hyperglycemia in STZ-induced diabetic rats by thiamine disulfide.Nutrition & diabetes · 2022Article
- The Effect of Diet and Lifestyle on the Course of Diabetic Retinopathy-A Review of the Literature.Nutrients · 2022Review
- Benfotiamine reduced collagen IV contents of sciatic nerve in hyperglycemic rats.Journal of diabetes and metabolic disorders · 2021Article
- Effects of Antioxidant Vitamins, Curry Consumption, and Heavy Metal Levels on Metabolic Syndrome with Comorbidities: A Korean Community-Based Cross-Sectional Study.Antioxidants (Basel, Switzerland) · 2021Article
- Thiamine reduced metabolic syndrome symptoms in rats via down-regulation of hepatic nuclear factor-kβ and induction activity of glyoxalase-I.Iranian journal of basic medical sciences · 2021Article
- Blood thiamine pyrophosphate concentration and its correlation with the stage of diabetic retinopathy.International ophthalmology · 2020Article
- Impaired nicotinamide adenine dinucleotide (NADJournal of diabetes investigation · 2020Review
- Alpha-lipoic acid alters the antitumor effect of bortezomib in melanoma cells in vitro.Scientific reports · 2020Article
- Nutritional and medical food therapies for diabetic retinopathy.Eye and vision (London, England) · 2020Review
- A Machine-Learning-Based Drug Repurposing Approach Using Baseline Regularization.Methods in molecular biology (Clifton, N.J.) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thiamine acts as a coenzyme for transketolase (Tk) and for the pyruvate dehydrogenase and α-ketoglutarate dehydrogenase complexes, enzymes which play a fundamental role for intracellular glucose metabolism. The relationship between thiamine and diabetes mellitus (DM) has been reported in the literature. Thiamine levels and thiamine-dependent enzyme activities have been reduced in DM. Genetic studies provide opportunity to link the relationship between thiamine and DM (such as Tk, SLC19A2 gene, transcription factor Sp1, α-1-antitrypsin, and p53). Thiamine and its derivatives have been demonstrated to prevent the activation of the biochemical pathways (increased flux through the polyol pathway, formation of advanced glycation end-products, activation of protein kinase C, and increased flux through the hexosamine biosynthesis pathway) induced by hyperglycemia in DM.Thiamine definitively has a role in the diabetic endothelial vascular diseases (micro and macroangiopathy), lipid profile, retinopathy, nephropathy, cardiopathy, and neuropathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.