ArticleApplied clinical informatics2012
Real-time pharmacy surveillance and clinical decision support to reduce adverse drug events in acute kidney injury: a randomized, controlled trial.
Article in Applied clinical informatics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- The effect of clinical decision support systems on clinical outcomes in acute kidney injury: a systematic review and meta-analysis of randomized controlled trials.Renal failure · 2024Pooled it
- Effect of electronic alerts on the care and outcomes in patients with acute kidney injury: a meta-analysis and trial sequential analysis.BMC medicine · 2024Pooled it
- Medication review in hospitalised patients to reduce morbidity and mortality.The Cochrane database of systematic reviews · 2023Pooled it
- Systematic review and narrative synthesis of computerized audit and feedback systems in healthcare.Journal of the American Medical Informatics Association : JAMIA · 2022Pooled it
- Reducing medication errors for adults in hospital settings.The Cochrane database of systematic reviews · 2021Pooled it
- Effect of clinical decision support systems on clinical outcome for acute kidney injury: a systematic review and meta-analysis.BMC nephrology · 2021Pooled it
- Electronic Alerts for Acute Kidney Injury.Deutsches Arzteblatt international · 2017Pooled it
- Meta-analysis of randomized controlled trials of electronic health interventions to reduce medication errors.NPJ digital medicine · 2025Article
- Why interventions to prevent acute kidney injury are needed now and why preventing long-term outcomes will only come later.Intensive care medicine · 2025Article
- The computerized algorithm for renal assessment improves diagnostic accuracy of renal impairment in hospitalized patients.Scientific reports · 2025Article
- Digital health and acute kidney injury: consensus report of the 27th Acute Disease Quality Initiative workgroup.Nature reviews. Nephrology · 2023Review
- Article
- Clinician collaboration to improve clinical decision support: the Clickbusters initiative.Journal of the American Medical Informatics Association : JAMIA · 2022Article
- A Narrative Review of Clinical Decision Support for Inpatient Clinical Pharmacists.Applied clinical informatics · 2021Review
- Impact of a computerized decision support tool deployed in two intensive care units on acute kidney injury progression and guideline compliance: a prospective observational study.Critical care (London, England) · 2020Observational
- Development and initial implementation of electronic clinical decision supports for recognition and management of hospital-acquired acute kidney injury.BMC medical informatics and decision making · 2020Article
- Improvement of drug prescribing in acute kidney injury with a nephrotoxic drug alert system.European journal of hospital pharmacy : science and practice · 2019Article
- Designing and evaluating an automated system for real-time medication administration error detection in a neonatal intensive care unit.Journal of the American Medical Informatics Association : JAMIA · 2018Observational
- Clinical Decision Support for In-Hospital AKI.Journal of the American Society of Nephrology : JASN · 2018Article
- Clinical Outcomes Used in Clinical Pharmacy Intervention Studies in Secondary Care.Pharmacy (Basel, Switzerland) · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectivesClinical decision support (CDS), such as computerized alerts, improves prescribing in the setting of acute kidney injury (AKI), but considerable opportunity remains to improve patient safety. The authors sought to determine whether pharmacy surveillance of AKI patients could detect and prevent medication errors that are not corrected by automated interventions.
methodsThe authors conducted a randomized clinical trial among 396 patients admitted to an academic, tertiary care hospital between June 1, 2010 and August 31, 2010 with an acute 0.5 mg/dl change in serum creatinine over 48 hours and a nephrotoxic or renally cleared medication order. Patients randomly assigned to the intervention group received surveillance from a clinical pharmacist using a web-based surveillance tool to monitor drug prescribing and kidney function trends. CDS alerting and standard pharmacy services were active in both study arms. Outcome measures included blinded adjudication of potential adverse drug events (pADEs), adverse drug events (ADEs) and time to provider modification or discontinuation of targeted nephrotoxic or renally cleared medications.
resultsPotential ADEs or ADEs occurred for 104 (8.0%) of control and 99 (7.1%) of intervention patient-medication pairs (p=0.4). Additionally, the time to provider modification or discontinuation of targeted nephrotoxic or renally cleared medications did not differ between control and intervention patients (33.4 hrs vs. 30.3 hrs, p=0.3).
conclusionsPharmacy surveillance had no incremental benefit over previously implemented CDS alerts.
Identifiers
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Registered trials
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