ArticleInternational journal of rheumatology2012
IgG4-Related Lymphadenopathy.
Article in International journal of rheumatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Atypical lymphoplasmacytic and immunoblastic proliferation: A Systematic Review.Journal of clinical and experimental hematopathology : JCEH · 2024Pooled it
- Surgical management of recurrent spinal hypertrophic pachymeningitis: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Are there atypical sites of IgG4 related disease in head and neck region? Personal experience and literature review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Review
- IgG4-related Disease Concomitant with Diffuse Large B-cell Lymphoma.Internal medicine (Tokyo, Japan) · 2025Article
- Tubulointerstitial nephritis with storiform fibrosis in a patient with angioimmunoblastic T-cell lymphoma.CEN case reports · 2025Article
- Article
- IgG4-related disease: Case report and 6-year follow-up of an elusive diagnosis mimicking malignancy.Clinical case reports · 2024Article
- An overlapping case of IgG4-related disease and systemic lupus erythematosus treated with belimumab: a case-based review.Rheumatology international · 2024Review
- A lymph node lesion of hyper IL-6 syndrome mimicking plasmacytoma, IgG4-related disease, and Castleman disease.Journal of clinical and experimental hematopathology : JCEH · 2024Article
- Article
- Immunoglobulin G4-related Ophthalmic Disease of the Caruncle: A Case Report.Korean journal of ophthalmology : KJO · 2022Article
- Report of Two Cases of Pediatric IgG4-Related Lymphadenopathy (IgG4-LAD): IgG4-Related Disease (IgG4-RD) or a Distinct Clinical Pathological Entity?Children (Basel, Switzerland) · 2022Article
- IgG4-related lung disease as a differential diagnosis of a lymphoproliferative disease: atypical presentation of an atypical disease.BMJ case reports · 2022Article
- Ossifying fibrous epulis as an IgG4-related disease of the oral cavity: a case report and literature review.BMC oral health · 2022Review
- Spectrum of B-cell neoplasms associated with immunoglobulin G4-related disease.Annals of hematology · 2022Article
- Investigation of IgG4-positive cells in idiopathic multicentric Castleman disease and validation of the 2020 exclusion criteria for IgG4-related disease.Pathology international · 2022Article
- [A case of IgG4-related disease with initial clinical manifestation of neck lymph nodes enlargement and literature review].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Review
- Short- and Long-Lived Autoantibody-Secreting Cells in Autoimmune Neurological Disorders.Frontiers in immunology · 2021Review
- Hemosiderin deposition in lymph nodes of patients with plasma cell-type Castleman disease.Journal of clinical and experimental hematopathology : JCEH · 2020Article
- Identifying clinical subgroups in IgG4-related disease patients using cluster analysis and IgG4-RD composite score.Arthritis research & therapy · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymphadenopathy is frequently observed in patients with immunoglobulin G4-related disease (IgG4-RD) and sometimes appears as the first manifestation of the disease. The diagnosis of IgG4-related lymphadenopathy is complicated owing to a great histological diversity, with at least 5 histological subtypes. Indeed, lymph node biopsy may be performed under the suspicion that the lymphadenopathy is a malignant lymphoma or other lymphoproliferative disorder. The diagnosis of IgG4-RD is characterized by both elevated serum IgG4 (>135 mg/dL) and histopathological features, including a dense lymphoplasmacytic infiltrate rich in IgG4(+) plasma cells (IgG4(+)/IgG(+) plasma cell ratio >40%). However, patients with hyper-interleukin (IL-) 6 syndromes such as multicentric Castleman's disease, rheumatoid arthritis, and other immune-mediated conditions frequently show lymph node involvement and often fulfill the diagnostic criteria for IgG4-RD. Owing to these factors, IgG4-RD cannot be differentiated from hyper-IL-6 syndromes on the basis of histological findings alone. Laboratory analyses are crucial to differentiate between the 2 diseases. Hyper-IL-6 syndromes are characterized by elevated serum levels of IgG, IgA, IgM, and C-reactive protein (CRP); thrombocytosis; anemia; hypoalbuminemia; hypocholesterolemia. In contrast, IgG4-RD does not share any of these characteristics. Therefore, the diagnosis of IgG4-RD requires not only pathological findings but also clinical and laboratory analyses.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.