ArticleInternational journal of cell biology2012
Nitric oxide inactivation mechanisms in the brain: role in bioenergetics and neurodegeneration.
Article in International journal of cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Nitric oxide in the occurrence and development of ischemic cerebrovascular disease.Medical gas research · 2027Review
- The multifaceted role of mitochondria in autism spectrum disorder.Molecular psychiatry · 2025Review
- Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury.Molecules (Basel, Switzerland) · 2023Article
- Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease.Molecules (Basel, Switzerland) · 2022Article
- Function and development of interneurons involved in brain tissue oxygen regulation.Frontiers in molecular neuroscience · 2022Review
- Modeling NO Biotransport in Brain Using a Space-Fractional Reaction-Diffusion Equation.Frontiers in physiology · 2021Article
- The Peculiar Facets of Nitric Oxide as a Cellular Messenger: From Disease-Associated Signaling to the Regulation of Brain Bioenergetics and Neurovascular Coupling.Neurochemical research · 2021Review
- The Potential Mechanisms of the Neuroprotective Actions of Oil Palm Phenolics: Implications for Neurodegenerative Diseases.Molecules (Basel, Switzerland) · 2020Review
- Nitric oxide regulates the firing rate of neuronal subtypes in the guinea pig ventral cochlear nucleus.The European journal of neuroscience · 2020Review
- Nitrosative Stress in the Frontal Cortex From Dogs With Canine Cognitive Dysfunction.Frontiers in veterinary science · 2020Article
- Gasotransmitter Heterocellular Signaling.Antioxidants & redox signaling · 2017Article
- Pathological Impact of the Interaction of NO and CO with Mitochondria in Critical Care Diseases.Frontiers in medicine · 2017Review
- Getting to NO Alzheimer's Disease: Neuroprotection versus Neurotoxicity Mediated by Nitric Oxide.Oxidative medicine and cellular longevity · 2016Review
- Beneficial effects of L-arginine on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuronal degeneration in substantia nigra of Balb/c mice.Advanced biomedical research · 2016Article
- A review of flux considerations for in vivo neurochemical measurements.The Analyst · 2015Review
- Effects of nitric oxide on magnocellular neurons of the supraoptic nucleus involve multiple mechanisms.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Review
- Bidirectional neuro-glial signaling modalities in the hypothalamus: role in neurohumoral regulation.Autonomic neuroscience : basic & clinical · 2013Review
- The complex contribution of NOS interneurons in the physiology of cerebrovascular regulation.Frontiers in neural circuits · 2012Article
- Hemoglobin: a nitric-oxide dioxygenase.Scientifica · 2012Review
- The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports.Signal transduction and targeted therapyReview
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the last decades nitric oxide ((•)NO) has emerged as a critical physiological signaling molecule in mammalian tissues, notably in the brain. (•)NO may modify the activity of regulatory proteins via direct reaction with the heme moiety, or indirectly, via S-nitrosylation of thiol groups or nitration of tyrosine residues. However, a conceptual understanding of how (•)NO bioactivity is carried out in biological systems is hampered by the lack of knowledge on its dynamics in vivo. Key questions still lacking concrete and definitive answers include those related with quantitative issues of its concentration dynamics and diffusion, summarized in the how much, how long, and how far trilogy. For instance, a major problem is the lack of knowledge of what constitutes a physiological (•)NO concentration and what constitutes a pathological one and how is (•)NO concentration regulated. The ambient (•)NO concentration reflects the balance between the rate of synthesis and the rate of breakdown. Much has been learnt about the mechanism of (•)NO synthesis, but the inactivation pathways of (•)NO has been almost completely ignored. We have recently addressed these issues in vivo on basis of microelectrode technology that allows a fine-tuned spatial and temporal measurement (•)NO concentration dynamics in the brain.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.