ReviewExperimental diabetes research2012
The use of functional MRI to study appetite control in the CNS.
Review in Experimental diabetes research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Testing of Food Images in Children
Brain Mechanisms of Overeating in Children
Who cites it
30 citing papers in PubMed, 104 citations in OpenAlex.
- Combination therapy with exenatide decreases the dapagliflozin-induced changes in brain responses to anticipation and consumption of palatable food in patients with type 2 diabetes: A randomized controlled trial.Diabetes, obesity & metabolism · 2022Trial
- Humans with obesity have disordered brain responses to food images during physiological hyperglycemia.American journal of physiology. Endocrinology and metabolism · 2018Trial
- Effects of Intranasal Oxytocin on the Blood Oxygenation Level-Dependent Signal in Food Motivation and Cognitive Control Pathways in Overweight and Obese Men.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Differential effects of L-tryptophan and L-leucine administration on brain resting state functional networks and plasma hormone levels.Scientific reports · 2016Trial
- Intestinal short-chain fatty acid turnover is not associated with resting state functional connectivity in mesolimbic dopaminergic network in healthy adults.Neuroimage. Reports · 2025Article
- Low-calorie diet-induced weight loss is associated with altered brain connectivity and food desire in obesity.Obesity (Silver Spring, Md.) · 2024Article
- Does Watching Mukbang and Cookbang Broadcasts Affect Subjective Body Image, Perceived Stress, and Physical Activity Levels among Korean Adolescents?Iranian journal of public health · 2024Article
- [Health behaviors and eating habits in people's 20s and 30s according to food content usage level on social media: a cross-sectional study].Korean journal of community nutrition · 2023Article
- Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions.Molecular psychiatry · 2023Review
- Influence of food images with different macronutrient compositions on serum ghrelin levels: Analysis in healthy males.Obesity science & practice · 2022Article
- Diet as connecting factor: Functional brain connectivity in relation to food intake and sucrose tasting, assessed with resting-state functional MRI in rats.Journal of neuroscience research · 2022Article
- Associations Between Asthma and Polycystic Ovary Syndrome: Current Perspectives.Frontiers in endocrinology · 2022Review
- Dextroamphetamine Treatment in Children With Hypothalamic Obesity.Frontiers in endocrinology · 2022Article
- Brain activations show association with subsequent endocrine responses to oral glucose challenge in a satiation-level dependent manner.Comprehensive psychoneuroendocrinology · 2021Article
- The Role of the Human Hypothalamus in Food Intake Networks: An MRI Perspective.Frontiers in nutrition · 2021Review
- Effect of Short-Term Transcutaneous Vagus Nerve Stimulation (tVNS) on Brain Processing of Food Cues: An Electrophysiological Study.Frontiers in human neuroscience · 2020Article
- Sense of Smell as the Central Driver of Pavlovian Appetite Behavior in Mammals.Frontiers in physiology · 2019Article
- Is the Brain a Key Player in Glucose Regulation and Development of Type 2 Diabetes?Frontiers in physiology · 2019Review
- Impact of Hunger, Satiety, and Oral Glucose on the Association Between Insulin and Resting-State Human Brain Activity.Frontiers in human neuroscience · 2019Article
- Brain reward responses to food stimuli among female monozygotic twins discordant for BMI.Brain imaging and behavior · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Functional magnetic resonance imaging (fMRI) has provided the opportunity to safely investigate the workings of the human brain. This paper focuses on its use in the field of human appetitive behaviour and its impact in obesity research. In the present absence of any safe or effective centrally acting appetite suppressants, a better understanding of how appetite is controlled is vital for the development of new antiobesity pharmacotherapies. Early functional imaging techniques revealed an attenuation of brain reward area activity in response to visual food stimuli when humans are fed-in other words, the physiological state of hunger somehow increases the appeal value of food. Later studies have investigated the action of appetite modulating hormones on the fMRI signal, showing how the attenuation of brain reward region activity that follows feeding can be recreated in the fasted state by the administration of anorectic gut hormones. Furthermore, differences in brain activity between obese and lean individuals have provided clues about the possible aetiology of overeating. The hypothalamus acts as a central gateway modulating homeostatic and nonhomeostatic drives to eat. As fMRI techniques constantly improve, functional data regarding the role of this small but hugely important structure in appetite control is emerging.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.