ReviewPLoS medicine2012
Clinical trials have gone global: is this a good thing?
Review in PLoS medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Operational complexities in international clinical trials: a systematic review of challenges and proposed solutions.BMJ open · 2024Pooled it
- Caregiver perceptions of nutrition interventions in infants and children under 24 months of age: a systematic review.Public health nutrition · 2023Pooled it
- Pooled it
- Barriers for conducting clinical trials in developing countries- a systematic review.International journal for equity in health · 2018Pooled it
- A critical appraisal of clinical trials conducted and subsequent drug approvals in India and South Africa.BMJ open · 2015Pooled it
- Ethnic background and genetic variation in the evaluation of cancer risk: a systematic review.PloS one · 2014Pooled it
- The IHAT-GUT Iron Supplementation Trial in Rural Gambia: Barriers, Facilitators, and Benefits.Nutrients · 2021Trial
- Challenges in conducting trials for pediatric tuberculous meningitis: lessons from the field.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2019Trial
- Unequal Access to Novel Systemic Therapies for Bladder Cancer: A Global Analysis of Clinical Trials of Immune Checkpoint Inhibitors and Antibody-Drug Conjugates.Current urology reports · 2026Review
- Commentary: Perceptions and attitudes toward clinical trial participation: a study onFrontiers in pharmacology · 2026Article
- Awareness, Willingness, and Concerns about Clinical Trial Participation among Iraqi Patients: A Cross-Sectional Study.Global heart · 2026Article
- Disease registries as foundational infrastructure for Contract Research Organisations in Africa.Journal of clinical and translational science · 2026Article
- Clinical Trial Ethical Challenges in Low- and Middle-Income Countries: A Review of Systematic Review.Research square · 2025Article
- The Heartbeat of Global Health.European journal of cardiovascular nursing · 2025Article
- Pilot implementation of short message service for randomisation in a multisite pragmatic factorial clinical trial in Kenya.Pilot and feasibility studies · 2025Article
- Unlocking the potential of Contract Research Organizations in Africa's clinical trials ecosystem.Journal of clinical and translational science · 2025Review
- Exploring healthcare workers' perceptions of child health research at Kamuzu Central Hospital, Malawi: an interpretative phenomenological analysis.Human resources for health · 2024Article
- Global trends in clinical trials involving engineered biomaterials.Science advances · 2024Review
- Global Equity in Clinical Trials: An ASCO Policy Statement.JCO global oncology · 2024Article
- Clinical trials landscape in a lower-middle-income country (Pakistan).Journal of clinical and translational science · 2024Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.