ArticleInternational journal of biological sciences2012
Co-methylated genes in different adipose depots of pig are associated with metabolic, inflammatory and immune processes.
Article in International journal of biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Prognostic role of myosteatosis in predicting MACE and mortality after TAVR: insights from CT-based body composition analysis.The journal of nutrition, health & aging · 2026Article
- Imbalance between skeletal muscle and intermuscular fat predicts treatment failure in Crohn's disease: an imaging biomarker for risk stratification.Annals of medicine · 2025Article
- Insights into intramuscular adipose-muscle signaling in the diabetic lower extremity.Journal of clinical & translational endocrinology · 2025Article
- microRNA-22 Inhibition Stimulates Mitochondrial Homeostasis and Intracellular Degradation Pathways to Prevent Muscle Wasting.International journal of molecular sciences · 2025Article
- Skeletal muscle adiposity, coronary microvascular dysfunction, and adverse cardiovascular outcomes.European heart journal · 2025Article
- Body composition derangements in lung cancer patients treated with first-line pembrolizumab: A multicentre observational study.Journal of cachexia, sarcopenia and muscle · 2024Observational
- Intermuscular adipose tissue accumulation is associated with higher tissue sodium in healthy individuals.Physiological reports · 2024Article
- Possible Mechanisms Linking Obesity, Steroidogenesis, and Skeletal Muscle Dysfunction.Life (Basel, Switzerland) · 2023Review
- Intermuscular adipose tissue in metabolic disease.Nature reviews. Endocrinology · 2023Review
- Quantifying the inflammatory secretome of human intermuscular adipose tissue.Physiological reports · 2022Article
- Dissecting the Gene Expression Networks Associated with Variations in the Major Components of the Fatty AcidAnimals : an open access journal from MDPI · 2021Article
- The Potential of Visceral Adipose Tissue in Distinguishing Clear Cell Renal Cell Carcinoma from Renal Angiomyolipoma with Minimal Fat.Cancer management and research · 2021Article
- Dietary intake of bioactive ingredients impacts liver and adipose tissue transcriptomes in a porcine model of prepubertal early obesity.Scientific reports · 2020Article
- Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans.American journal of physiology. Endocrinology and metabolism · 2019Article
- Characterization of Cytosine Methylation and the DNA Methyltransferases ofInternational journal of biological sciences · 2017Article
- Genome-Wide Association Study for Carcass Traits in an Experimental Nelore Cattle Population.PloS one · 2017Article
- DNA methylation landscape of fat deposits and fatty acid composition in obese and lean pigs.Scientific reports · 2016Article
- The genetics of fat distribution.Diabetologia · 2014Review
- Molecular heterogeneities of adipose depots - potential effects on adipose-muscle cross-talk in humans, mice and farm animals.Journal of genomics · 2014Review
- SERPINE1, PAI-1 protein coding gene, methylation levels and epigenetic relationships with adiposity changes in obese subjects with metabolic syndrome features under dietary restriction.Journal of clinical biochemistry and nutrition · 2013Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well established that the metabolic risk factors of obesity and its comorbidities are more attributed to adipose tissue distribution rather than total adipose mass. Since emerging evidence suggests that epigenetic regulation plays an important role in the aetiology of obesity, we conducted a genome-wide methylation analysis on eight different adipose depots of three pig breeds living within comparable environments but displaying distinct fat level using methylated DNA immunoprecipitation sequencing. We aimed to investigate the systematic association between anatomical location-specific DNA methylation status of different adipose depots and obesity-related phenotypes. We show here that compared to subcutaneous adipose tissues which primarily modulate metabolic indicators, visceral adipose tissues and intermuscular adipose tissue, which are the metabolic risk factors of obesity, are primarily associated with impaired inflammatory and immune responses. This study presents epigenetic evidence for functionally relevant methylation differences between different adipose depots.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.