ArticleWorld journal of gastroenterology2012
Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: a research study.
Article in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Liver Damage and microRNAs: An Update.Current issues in molecular biology · 2022Review
- Circulating microRNA Profiles in Acetaminophen Toxicity.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2020Observational
- MicroRNAs as biomarkers for liver injury: Current knowledge, challenges and future prospects.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2017Review
- Translational biomarkers of acetaminophen-induced acute liver injury.Archives of toxicology · 2015Review
- MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury.Journal of clinical medicine · 2015Review
- microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment.Biomarkers in medicine · 2015Review
- Use of miRNAs as biomarkers in sepsis.Analytical cellular pathology (Amsterdam) · 2015Review
- MicroRNAs in Drug-induced Liver Injury.Journal of clinical and translational hepatology · 2014Review
- Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients.Expert opinion on drug metabolism & toxicology · 2014Review
- Incubation of whole blood at room temperature does not alter the plasma concentrations of microRNA-16 and -223.Drug metabolism and disposition: the biological fate of chemicals · 2013Article
- MicroRNAs in Liver Disease: Bench to Bedside.Journal of clinical and experimental hepatology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
aimTo investigate plasma microRNA (miRNA) profiles indicative of hepatotoxicity in the setting of lethal acetaminophen (APAP) toxicity in mice.
methodsUsing plasma from APAP poisoned mice, either lethally (500 mg/kg) or sublethally (150 mg/kg) dosed, we screened commercially available murine microRNA libraries (SABiosciences, Qiagen Sciences, MD) to evaluate for unique miRNA profiles between these two dosing parameters.
resultsWe distinguished numerous, unique plasma miRNAs both up- and downregulated in lethally compared to sublethally dosed mice. Of note, many of the greatest up- and downregulated miRNAs, namely 574-5 p, 466 g, 466 f-3p, 375, 29 c, and 148 a, have been shown to be associated with asthma in prior studies. Interestingly, a relationship between APAP and asthma has been previously well described in the literature, with an as yet unknown mechanism of pathology. There was a statistically significant increase in alanine aminotransferase levels in the lethal compared to sublethal APAP dosing groups at the 12 h time point (P < 0.001). There was 90% mortality in the lethally compared to sublethally dosed mice at the 48 h time point (P = 0.011).
conclusionWe identified unique plasma miRNAs both up- and downregulated in APAP poisoning which are correlated to asthma development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.