ArticleJournal of the Royal Society, Interface2012
Revealing mechanisms underlying variation in malaria virulence: effective propagation and host control of uninfected red blood cell supply.
Article in Journal of the Royal Society, Interface, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- From Plato to Pareto: Defining the shape of infection's disease space.Science advances · 2026Article
- The role of the spleen in red blood cell loss caused by malaria: A mathematical model.PLoS computational biology · 2026Article
- Higher body condition with infection byPeerJ · 2024Article
- Article
- Differential drivers of intraspecific and interspecific competition during malaria-helminth co-infection.Parasitology · 2021Article
- Immune selection suppresses the emergence of drug resistance in malaria parasites but facilitates its spread.PLoS computational biology · 2021Article
- Uncovering drivers of dose-dependence and individual variation in malaria infection outcomes.PLoS computational biology · 2020Article
- Phenotypic plasticity in reproductive effort: malaria parasites respond to resource availability.Proceedings. Biological sciences · 2017Article
- A nutrient mediates intraspecific competition between rodent malaria parasitesProceedings. Biological sciences · 2017Article
- Review
- Opportunities and challenges of Integral Projection Models for modelling host-parasite dynamics.The Journal of animal ecology · 2016Article
- Article
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Malaria parasite clones with the highest transmission rates to mosquitoes also tend to induce the most severe fitness consequences (or virulence) in mammals. This is in accord with expectations from the virulence-transmission trade-off hypothesis. However, the mechanisms underlying how different clones cause virulence are not well understood. Here, using data from eight murine malaria clones, we apply recently developed statistical methods to infer differences in clone characteristics, including induction of differing host-mediated changes in red blood cell (RBC) supply. Our results indicate that the within-host mechanisms underlying similar levels of virulence are variable and that killing of uninfected RBCs by immune effectors and/or retention of RBCs in the spleen may ultimately reduce virulence. Furthermore, the correlation between clone virulence and the degree of host-induced mortality of uninfected RBCs indicates that hosts increasingly restrict their RBC supply with increasing intrinsic virulence of the clone with which they are infected. Our results demonstrate a role for self-harm in self-defence for hosts and highlight the diversity and modes of virulence of malaria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.