ArticleMolecular biology reports2012
The SNPs in the ACACA gene are effective on fatty acid composition in Holstein milk.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
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- HSF1 and CPSF1 affect milk fat and protein synthesis by regulating the AKT/mTOR signaling pathway.Journal of animal science · 2025Article
- Regulation of Milk Fat Synthesis: Key Genes and Microbial Functions.Microorganisms · 2024Review
- Whole Genome Scan Uncovers Candidate Genes Related to Milk Production Traits in Barka Cattle.International journal of molecular sciences · 2024Article
- Genomic analysis uncovers novel candidate genes related to adaptation to tropical climates and milk production traits in native goats.BMC genomics · 2024Article
- Identification of Copy Number Variations and Selection Signatures in Wannan Spotted Pigs by Whole Genome Sequencing Data: A Preliminary Study.Animals : an open access journal from MDPI · 2024Article
- Poly-Aesthetic surgery journal. Open forum · 2024Article
- Integrated transcriptomic and proteomic analyses reveal the mechanism of easy acceptance of artificial pelleted diets during food habit domestication in Largemouth bass (Micropterus salmoides).Scientific reports · 2023Article
- Review: genetic background of milk fatty acid synthesis in bovines.Tropical animal health and production · 2023Review
- Identification of Genetic Polymorphisms of PI, PIII, and Exon 53 in the Acetyl-CoA Carboxylase-α (ACACα) Gene and Their Association with Milk Composition Traits of Najdi Sheep.Animals : an open access journal from MDPI · 2023Article
- Using QTL to Identify Genes and Pathways Underlying the Regulation and Production of Milk Components in Cattle.Animals : an open access journal from MDPI · 2023Review
- Article
- Restoration of the adipogenic gene expression by naringenin and naringin in 3T3-L1 adipocytes.Journal of veterinary science · 2021Article
- RNA-Seq based genetic variant discovery provides new insights into controlling fat deposition in the tail of sheep.Scientific reports · 2020Article
- Comparative analysis of the skim milk and milk fat globule membrane proteomes produced by Jersey cows grazing pastures with different plant species diversity.Journal of dairy science · 2020Article
- Impact of SNPs inAnimals : an open access journal from MDPI · 2020Article
- Current Evidences and Future Perspectives for AMPK in the Regulation of Milk Production and Mammary Gland Biology.Frontiers in cell and developmental biology · 2020Review
- Identification of key pathways and genes in different types of chronic kidney disease based on WGCNA.Molecular medicine reports · 2019Article
- Single Nucleotide Polymorphisms ofGenes · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatty acid composition is an important economic trait for both dairy and beef cattle and controlled by genetic factors. Candidate genes controlling fatty acid composition may be found in fat synthesis and metabolism pathways. Acetyl-CoA carboxylase is the flux-determining enzyme in the regulation of fatty acid synthesis in animal tissues. One of two isozymes of this enzyme, acetyl-CoA carboxylase-α (ACACA), catalyses the first committed step of fatty acid synthesis in mammalian cytosol, leading to the biosynthesis of long-chain fatty acids. In the current study, the sequence comparison of the coding sequence (CDS) and two promoter regions (PIA and PIII) in bovine ACACA gene was performed between Japanese Black and Holstein cattle to detect nucleotide polymorphisms influencing fatty acid composition in milk and beef. Five single nucleotide polymorphisms (SNPs) were identified in the CDS region, 28 SNPs in the PIA region and three SNPs in the PIII region. Association study revealed that CCT/CCT type of PIII_#1, #2/PIA_#26 indicated a higher percentage of C14:0 in the milk of the Holstein cattle than CCT/GTC type (p = 0.050) and that a difference of the percentage of C16:0 was observed between CCT/CCT and GTC/GTC type (p = 0.023). CDS_#2 T/T type indicated a higher percentage of C18:0 than T/C type (p = 0.008). In addition, the Japanese Black cattle with CC/GT type of PIII_#1, #2 showed a higher percentage of C18:2 in the meat than those with GT/GT type (p = 0.025). Since PIII is the promoter specific to mammary gland during lactation, the altered expression of the ACACA gene owing to the SNPs in the PIII region may influence the fatty acid composition in the milk.
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