ArticleMucosal immunology2013
Reduced severity of peanut-induced anaphylaxis in TLR9-deficient mice is associated with selective defects in humoral immunity.
Article in Mucosal immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Metabolic fitness of IgAMucosal immunology · 2024Article
- Exploring the links between necrotizing enterocolitis and cow's milk protein allergy in preterm infants: a narrative review.Frontiers in pediatrics · 2023Review
- B Cell Responses in the Development of Mammalian Meat Allergy.Frontiers in immunology · 2020Review
- Cutaneous Exposure to Clinically Relevant Lone Star Ticks Promotes IgE Production and Hypersensitivity through CD4Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- The chemokine receptor CCR1 is identified in mast cell-derived exosomes.American journal of translational research · 2018Article
- A leukocyte activation test identifies food items which induce release of DNA by innate immune peripheral blood leucocytes.Nutrition & metabolism · 2018Article
- Microbiome and food allergy.Translational research : the journal of laboratory and clinical medicine · 2017Review
- Role of Maternal Dietary Peanut Exposure in Development of Food Allergy and Oral Tolerance.PloS one · 2015Article
- The immunology of food allergy.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
- Lymphocyte-based model systems for allergy research: a historic overview.International archives of allergy and immunology · 2014Review
- Developing therapies for peanut allergy.International archives of allergy and immunology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Signaling through the innate immune system can promote or suppress allergic sensitization. Toll-like receptor 9 (TLR9) has modulatory effects on the mucosal immune system, and we hypothesized that TLR9 would influence susceptibility to allergic sensitization to foods. We observed that TLR9-/- mice were resistant to peanut-induced anaphylaxis. This was associated with a significant impairment in total immunoglobulin E (IgE) and peanut-specific IgE and IgA, but not IgG1 or Th2 cytokine production. TLR9-/- mice had reduced development of Peyer's patches, but resistance to sensitization was not restricted to oral routes. Rag1-deficient mice were reconstituted with TLR9+/+ or -/- B cells plus CD4+ T cells. TLR9-/- B cells regained the ability to produce IgE in the presence of a wild-type environment. Our results demonstrate that TLR9 on an unknown cell type is required for the development of IgE-producing B cells, and we conclude that TLR9 signaling indirectly shapes the immune response for optimal IgE production.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.