ArticleKidney international2012
Blood pressure levels and mortality risk among hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study.
Article in Kidney international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03459807 (BOLD), which is not on this map. Cited by 71 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BOLD: A Trial of Blood Pressure Lowering in Dialysis
Who cites it
71 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Management of blood pressure in adults, children and young people on dialysis: UK kidney association clinical practice guideline.BMC nephrology · 2025Guideline
- Guideline
- Blood pressure and volume management in dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.Kidney international · 2020Guideline
- Taking a Step Further in Identifying Ideal Blood Pressure Range Among Hemodialysis Patients: A Systematic Review and a Meta-Analysis.Frontiers in pharmacology · 2020Pooled it
- I Brazilian guideline on hypertension in dialysis of the Brazilian Society of Nephrology.Jornal brasileiro de nefrologiaGuideline
- Efficacy of a Web-Based Home Blood Pressure Monitoring Program in Improving Predialysis Blood Pressure Control Among Patients Undergoing Hemodialysis: Randomized Controlled Trial.JMIR mHealth and uHealth · 2024Trial
- Treating Home Versus Predialysis Blood Pressure Among In-Center Hemodialysis Patients: A Pilot Randomized Trial.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Trial
- BP in Dialysis: Results of a Pilot Study.Journal of the American Society of Nephrology : JASN · 2018Trial
- Blood volume-monitored regulation of ultrafiltration to decrease the dry weight in fluid-overloaded hemodialysis patients: a randomized controlled trial.BMC nephrology · 2017Trial
- Effects of spironolactone on dialysis patients with refractory hypertension: a randomized controlled study.Journal of clinical hypertension (Greenwich, Conn.) · 2014Trial
- Intensive vs Standard Blood Pressure Lowering in People With and Without Chronic Kidney Disease: A Systematic Review and Meta-Analysis.JAMA cardiology · 2026Article
- Fluid overload modifies ambulatory blood pressure and pulse wave characteristics in hemodialysis patients undergoing targeted fluid management.Clinical kidney journal · 2026Article
- Age-stratified association between blood pressure and clinical outcomes in maintenance hemodialysis patients.International urology and nephrology · 2026Article
- Home Blood Pressure Phenotypes and Cardiovascular Remodeling in Hemodialysis.Kidney international reports · 2026Article
- Managing Blood Pressure in Dialysis Patients: A Summary of UK Clinical Practice Guideline.Kidney international reports · 2026Article
- Effects of hospitalization before hemodialysis on mortality in dialysis patients.BMC geriatrics · 2025Article
- Combined pre-dialysis systolic blood pressure and pulse rate assessment for 1-year all-cause and cardiovascular mortality in patients on hemodialysis: a nationwide cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Association of the remnant cholesterol to high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients.Lipids in health and disease · 2025Article
- Target blood pressure in Korean hemodialysis patients for optimal survival.Kidney research and clinical practice · 2025Article
- Association Between Blood Pressure Variation During Dialysis and Cardio-Cerebrovascular Events.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
KDOQI practice guidelines recommend predialysis blood pressure <140/90 mm Hg; however, most prior studies had found elevated mortality with low, not high, systolic blood pressure. This is possibly due to unmeasured confounders affecting systolic blood pressure and mortality. To lessen this bias, we analyzed 24,525 patients by Cox regression models adjusted for patient and facility characteristics. Compared with predialysis systolic blood pressure of 130-159 mm Hg, mortality was 13% higher in facilities with 20% more patients at systolic blood pressure of 110-129 mm Hg and 16% higher in facilities with 20% more patients at systolic blood pressure of ≥160 mm Hg. For patient-level systolic blood pressure, mortality was elevated at low (<130 mm Hg), not high (≥180 mm Hg), systolic blood pressure. For predialysis diastolic blood pressure, mortality was lowest at 60-99 mm Hg, a wide range implying less chance to improve outcomes. Higher mortality at systolic blood pressure of <130 mm Hg is consistent with prior studies and may be due to excessive blood pressure lowering during dialysis. The lowest risk facility systolic blood pressure of 130-159 mm Hg indicates this range may be optimal, but may have been influenced by unmeasured facility practices. While additional study is needed, our findings contrast with KDOQI blood pressure targets, and provide guidance on optimal blood pressure range in the absence of definitive clinical trial data.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.