Evidence map›Paper›PMID 22717771›Full record

ReviewClinical immunology (Orlando, Fla.)2012

Lymph node vascular-stromal growth and function as a potential target for controlling immunity.

Fairouz Benahmed, Scott Ely, Theresa T Lu

Abstract readReview
In one paragraph

Review in Clinical immunology (Orlando, Fla.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Fairouz BenahmedAutoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA. BenahmedF@hss.edu
Scott Ely
Theresa T Lu

Funding

Vascular-stromal function and regulation in immunityR01AI079178 · NIAID · HOSPITAL FOR SPECIAL SURGERY · PI Theresa T. Lu · 2010 to 2026
$6.6M
Lymphoid Tissue Microvessel GrowthR01AI068900 · NIAID · HOSPITAL FOR SPECIAL SURGERY · PI LU, THERESA T. · 2007 to 2011
$1.9M
NIAID NIH HHS R01 AI068900NIAID NIH HHS R01 AI079178
6 · The paper itself

Abstract

Lymphadenopathy occurs in many autoimmune and inflammatory diseases, and vascular proliferation is a common feature in the enlarged lymph nodes. The lymph node vasculature plays critical roles in delivering immune cells as well as oxygen and micronutrients, and therefore represents a potential target for therapeutic manipulation of immunity. In this review, we discuss recent insights made in understanding the growth and function of the vascular and associated stromal compartment in immune-stimulated lymph nodes and the potential utility of altering this process in autoimmune diseases.

Indexed as

AnimalsAutoimmune DiseasesBlood VesselsEndothelial CellsHumansLymphatic VesselsLymph NodesStromal Cells

Identifiers

PMID22717771
PMCPMC3932544

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.