Evidence map›Paper›PMID 22717698›Full record

ReviewCurrent pain and headache reports2012

Brain imaging in fibromyalgia.

Liliana Lourenço Jorge, Edson Amaro

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pain and headache reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

  1. Nociplastic pain: controversy of the concept.The Korean journal of pain · 2025
    Review
  2. Novel Approaches in Molecular Imaging and Neuroimaging of Fibromyalgia.International journal of molecular sciences · 2022
    Review
  3. Predictive Bidirectional Relations Between Pain, Fatigue, and Dyscognition in Fibromyalgia.Mayo Clinic proceedings. Innovations, quality & outcomes · 2022
    Article
  4. Article
  5. Review
  6. Ocular neuropathic pain.The British journal of ophthalmology · 2016
    Review
  7. Fibromyalgia: A Critical and Comprehensive Review.Clinical reviews in allergy & immunology · 2015
    Review
  8. Article
  9. Can neural markers be used for fibromyalgia clinical management?Principles and practice of clinical research (2015)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Liliana Lourenço JorgeHospital Israelita Albert Einstein and Instituto de Reabilitação Lucy Montoro, Avenida Albert Einstein, 627 3rd Floor Block D, 05651901, Morumbi, Sao Paulo, Brazil. lilianalj@einstein.br
Edson Amaro
Hospital Israelita Albert Einstein · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibromyalgia is a primary brain disorder or a result of peripheral dysfunctions inducing brain alterations, with underlying mechanisms that partially overlap with other painful conditions. Although there are methodologic variations, neuroimaging studies propose neural correlations to clinical findings of abnormal pain modulation in fibromyalgia. Growing evidences of specific differences of brain activations in resting states and pain-evoked conditions confirm clinical hyperalgesia and impaired inhibitory descending systems, and also demonstrate cognitive-affective influences on painful experiences, leading to augmented pain-processing. Functional data of neural activation abnormalities parallel structural findings of gray matter atrophy, alterations of intrinsic connectivity networks, and variations in metabolites levels along multiple pathways. Data from positron-emission tomography, single-photon-emission-computed tomography, blood-oxygen-level-dependent, voxel-based morphometry, diffusion tensor imaging, default mode network analysis, and spectroscopy enable the understanding of fibromyalgia pathophysiology, and favor the future establishment of more tailored treatments.

Indexed as

BrainFibromyalgiaFunctional NeuroimagingHumansMagnetic Resonance ImagingPositron-Emission TomographyTomography, Emission-Computed, Single-Photon

Identifiers

PMID22717698
OpenAlexW1992558622

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.