ArticleIntensive care medicine2012
Improvement of left ventricular relaxation as assessed by tissue Doppler imaging in fluid-responsive critically ill septic patients.
Article in Intensive care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03198611 (Early Reversibility of Diastolic Disfunction as a Prognostic Factor in Septic Shock), which is not on this map. Cited by 29 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Reversibility of Diastolic Disfunction as a Prognostic Factor in Septic Shock
Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Fluid challenge in critically ill patients receiving haemodynamic monitoring: a systematic review and comparison of two decades.Critical care (London, England) · 2022Pooled it
- Systematic review including re-analyses of 1148 individual data sets of central venous pressure as a predictor of fluid responsiveness.Intensive care medicine · 2016Pooled it
- Diastolic dysfunction and mortality in septic patients: a systematic review and meta-analysis.Intensive care medicine · 2015Pooled it
- Physiological changes after fluid bolus therapy in sepsis: a systematic review of contemporary data.Critical care (London, England) · 2014Pooled it
- Association between 30-day mortality and serially measured hematologic markers in patients with septic shock in South Korea.Acute and critical care · 2026Article
- Serial bedside echocardiography identifies children at risk of recurrent Dengue shock: a prospective cohort study.BMC emergency medicine · 2026Article
- Fluid challenge and left ventricular myocardial performance index assessed by transthoracic echocardiography with tissue Doppler imaging in critically ill patients with regular rhythm.Frontiers in medicine · 2026Article
- Critical Care Ultrasound in Shock: A Comprehensive Review of Ultrasound Protocol for Hemodynamic Assessment in the Intensive Care Unit.Journal of clinical medicine · 2024Review
- The elusive relationship between cardiac filling and fluid responsiveness.Critical care (London, England) · 2024Article
- Sepsis-Induced myocardial dysfunction: heterogeneity of functional effects and clinical significance.Frontiers in cardiovascular medicine · 2023Review
- Left Ventricular Diastolic Dysfunction in ARDS Patients.Journal of clinical medicine · 2022Article
- Accuracy of pulse pressure variations for fluid responsiveness prediction in mechanically ventilated patients with biphasic positive airway pressure mode.Journal of clinical monitoring and computing · 2022Article
- Assessing Fluid Intolerance with Doppler Ultrasonography: A Physiological Framework.Medical sciences (Basel, Switzerland) · 2022Review
- Role of Electromechanical Dyssynchrony Assessment During Acute Circulatory Failure and Its Relation to Ventriculo-Arterial Coupling.Frontiers in cardiovascular medicine · 2022Article
- Echocardiographic Assessment of Left Ventricular Systolic and Diastolic Functions in Dogs with Severe Sepsis and Septic Shock; Longitudinal Study.Animals : an open access journal from MDPI · 2021Article
- Assessment of left-ventricular diastolic function in pediatric intensive-care patients: a review of parameters and indications compared with those for adults.World journal of pediatrics : WJP · 2021Review
- Observational
- Diastolic dysfunction of the left ventricle - a practical approach for an anaesthetist.Anaesthesiology intensive therapy · 2020Review
- Time course of fluid responsiveness in sepsis: the fluid challenge revisiting (FCREV) study.Critical care (London, England) · 2019Observational
- Pathophysiology, echocardiographic evaluation, biomarker findings, and prognostic implications of septic cardiomyopathy: a review of the literature.Critical care (London, England) · 2018Review
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLeft ventricular (LV) diastolic function is often impaired in critically ill septic patients. The peak velocity of the mitral annulus early wave during diastole (E'), measured by Doppler echocardiography, is a major tool to evaluate LV relaxation, the ATP-dependent part of diastole. The authors hypothesized that if volume expansion (VE) is followed by an increase in stroke volume (SV) ("adequate" VE), LV relaxation and consequently E' may be increased.
methodsThis was a prospective study in which 83 mechanically ventilated septic patients with circulatory failure were enrolled. Doppler echocardiography was performed before and after the infusion of 500 ml of saline over 20 min. Patients were then classified into two groups according to their response to VE: responders (R) were those in whom SV increased by at least 15 %; all others were considered to be non-responders (NR). SV, mitral flow early wave velocity (E), E' and the E/E' ratio were measured before and after VE. VE-induced variations (∆) in all parameters were compared in R and NR. Patients with an E' < 0.12 m/s were considered to have LV diastolic dysfunction.
resultsFifty-nine patients (71 %) were R and 24 (29 %) were NR. Fifty-six percent of R patients and 58 % of NR patients had LV diastolic dysfunction. For patients with LV diastolic dysfunction (n = 47), ∆E' was significantly higher in the R group (29 ± 5 vs. 5 ± 8 %; p = 0.01) whilst ∆E/E' was higher in the NR group (35 ± 9 vs. 2 ± 6 %; p = 0.02).
conclusionsE' maximal velocity increased with adequate VE, suggesting an improvement of LV relaxation with the correction of hypovolaemia in patients with septic shock.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.