ArticleNature chemistry2012
Protein camouflage in cytochrome c-calixarene complexes.
Article in Nature chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed.
- A Rigid Supramolecular Solution to a Flexible Problem: A Multifunctional Calix[4]arene-Based Strategy to Prevent α‑Synuclein Toxicity.ACS central science · 2026Article
- Protein Recognition and Assembly by a Phosphocavitand.Journal of the American Chemical Society · 2025Article
- Modular protein frameworks via supramolecular synthons.Biophysical reviews · 2025Review
- N-Terminal Protein Binding and Disorder-to-Order Transition by a Synthetic Receptor.Biochemistry · 2025Article
- Thiacalixarene Carboxylic Acid Derivatives as Inhibitors of Lysozyme Fibrillation.International journal of molecular sciences · 2024Article
- How Do Molecular Tweezers Bind to Proteins? Lessons from X-ray Crystallography.Molecules (Basel, Switzerland) · 2024Review
- Modulation of the Fibrillation Kinetics and Morphology of a Therapeutic Peptide by Cucurbit[7]uril.Molecular pharmaceutics · 2023Article
- Complex Formation between CytochromeInternational journal of molecular sciences · 2022Article
- Protein-Calixarene Complexation: From Recognition to Assembly.Accounts of chemical research · 2022Article
- Protein Frameworks with Thiacalixarene and Zinc.Crystal growth & design · 2022Article
- Exploring the Binding Mechanism of a Supramolecular Tweezer CLR01 to 14-3-3σ ProteinFrontiers in chemistry · 2022Article
- Protein Assembly by Design.Chemical reviews · 2021Review
- Anthocyanin Color Stabilization by Host-Guest Complexation withMolecules (Basel, Switzerland) · 2021Article
- Modulation of Src Kinase Activity by Selective Substrate Recognition with Pseudopeptidic Cages.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Light-driven release of cucurbit[8]uril from a bivalent cage.Chemical science · 2021Article
- Specific inhibition of the Survivin-CRM1 interaction by peptide-modified molecular tweezers.Nature communications · 2021Article
- Noncovalent Protein-Pseudorotaxane Assembly Incorporating an Extended Arm Calix[8]arene with α-Helical Recognition Properties.Crystal growth & design · 2021Article
- Selective Recognition of Amino Acids and Peptides by Small Supramolecular Receptors.Molecules (Basel, Switzerland) · 2020Review
- Synthesis and Glycosidase Inhibition Properties of Calix[8]arene-Based Iminosugar Click Clusters.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Atomic Details of Carbon-Based Nanomolecules Interacting with Proteins.Molecules (Basel, Switzerland) · 2020Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small molecules that recognize protein surfaces are important tools for modifying protein interaction properties. Since the 1980s, several thousand studies concerning calixarenes and host-guest interactions have been published. Although there is growing interest in protein-calixarene interactions, only limited structural information has been available to date. We now report the crystal structure of a protein-calixarene complex. The water-soluble p-sulfonatocalix[4]arene is shown to bind the lysine-rich cytochrome c at three different sites. Binding curves obtained from NMR titrations reveal an interaction process that involves two or more binding sites. Together, the data indicate a dynamic complex in which the calixarene explores the surface of cytochrome c. In addition to providing valuable information on protein recognition, the data also indicate that the calixarene is a mediator of protein-protein interactions, with potential applications in generating assemblies and promoting crystallization.
Indexed as
Identifiers
22717436What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.