ArticlePsychological medicine2012
Prospective study of cannabis use in adolescents at clinical high risk for psychosis: impact on conversion to psychosis and functional outcome.
Article in Psychological medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
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The trial behind it
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Cannabis use in individuals at clinical high-risk for psychosis: a comprehensive review.Social psychiatry and psychiatric epidemiology · 2020Pooled it
- Are cannabis-using and non-using patients different groups? Towards understanding the neurobiology of cannabis use in psychotic disorders.Journal of psychopharmacology (Oxford, England) · 2018Pooled it
- Clinical high risk for psychosis in children and adolescents: a systematic review.European child & adolescent psychiatry · 2018Pooled it
- Cannabis use and symptom severity in individuals at ultra high risk for psychosis: a meta-analysis.Acta psychiatrica Scandinavica · 2017Pooled it
- Occasional cannabis use is associated with higher premorbid functioning and IQ in youth at clinical high-risk (CHR) for psychosis: Parallel findings to psychosis cohorts.Schizophrenia research · 2024Article
- The relationship between substance use and self-reported aspects of social functioning in patients with a psychotic disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Using Task-fMRI to Explore the Relationship Between Lifetime Cannabis Use and Cognitive Control in Individuals With First-Episode Schizophrenia.Schizophrenia bulletin open · 2024Article
- Influence of cannabis use on incidence of psychosis in people at clinical high risk.Psychiatry and clinical neurosciences · 2023Article
- Ethnoracial discrimination and the development of suspiciousness symptoms in individuals at clinical high-risk for psychosis.Schizophrenia research · 2023Article
- The impact of early factors on persistent negative symptoms in youth at clinical high risk for psychosis.Frontiers in psychiatry · 2023Article
- Neurobehavioral risk factors influence prevalence and severity of hazardous substance use in youth at genetic and clinical high risk for psychosis.Frontiers in psychiatry · 2023Article
- Cannabinoids, reward processing, and psychosis.Psychopharmacology · 2022Review
- Impact of smoking Behavior on cognitive functioning in persons at risk for psychosis and healthy controls: A longitudinal study.European psychiatry : the journal of the Association of European Psychiatrists · 2021Article
- Factors Moderating the Association Between Cannabis Use and Psychosis Risk: A Systematic Review.Brain sciences · 2020Review
- Key Worker-Mediated Enhancement of Physical Health in First Episode Psychosis: Protocol For a Feasibility Study in Primary Care.JMIR research protocols · 2019Article
- What prevents youth at clinical high risk for psychosis from engaging in physical activity? An examination of the barriers to physical activity.Schizophrenia research · 2018Article
- Monitoring of physical health in services for young people at ultra-high risk of psychosis.Early intervention in psychiatry · 2018Article
- The relationship between cannabis use and cortisol levels in youth at ultra high-risk for psychosis.Psychoneuroendocrinology · 2017Article
- Multisubstance Use Among Treatment-Seeking Smokers: Synergistic Effects of Coping Motives for Cannabis and Alcohol Use and Social Anxiety/Depressive Symptoms.Substance use & misuse · 2016Article
- Functional deterioration from the premorbid period to 2 years after the first episode of psychosis in early-onset psychosis.European child & adolescent psychiatry · 2015Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundClinical and epidemiological studies suggest an association between cannabis use and psychosis but this relationship remains controversial.
methodClinical high-risk (CHR) subjects (age 12-22 years) with attenuated positive symptoms of psychosis (CHR+, n=101) were compared to healthy controls (HC, n=59) on rates of substance use, including cannabis. CHR+ subjects with and without lifetime cannabis use (and abuse) were compared on prodromal symptoms and social/role functioning at baseline. Participants were followed an average of 2.97 years to determine psychosis conversion status and functional outcome.
resultsAt baseline, CHR+ subjects had significantly higher rates of lifetime cannabis use than HC. CHR+ lifetime cannabis users (n=35) were older (p=0.015, trend), more likely to be Caucasian (p=0.002), less socially anhedonic (p<0.001) and had higher Global Functioning: Social (GF:Social) scores (p<0.001) than non-users (n=61). CHR+ cannabis users continued to have higher social functioning than non-users at follow-up (p<0.001) but showed no differences in role functioning. A small sample of CHR+ cannabis abusers (n=10) showed similar results in that abusers were older (p=0.008), less socially anhedonic (p=0.017, trend) and had higher baseline GF:Social scores (p=0.006) than non-abusers. Logistic regression analyses revealed that conversion to psychosis in CHR+ subjects (n=15) was not related to lifetime cannabis use or abuse.
conclusionsThe current data do not indicate that low to moderate lifetime cannabis use is a major contributor to psychosis or poor social and role functioning in clinical high-risk youth with attenuated positive symptoms of psychosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.