ArticleBMC genomics2012
The immune gene repertoire of an important viral reservoir, the Australian black flying fox.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.
- A metaanalysis of bat phylogenetics and positive selection based on genomes and transcriptomes from 18 species.Proceedings of the National Academy of Sciences of the United States of America · 2019Pooled it
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- Atlas of gross, histologic, and immunohistologic anatomy of the lymphoid system in Egyptian rousettes (Rousettus aegyptiacus).Veterinary research · 2026Article
- Immunoglobulin heavy chain locus duplication in bats.Science advances · 2026Article
- Comparative transcriptome analysis unveils unique antiviral immune signatures ofFrontiers in immunology · 2026Article
- Annotation of bat IG H/L/K loci and analysis of the characteristics of bat BCR-CDR3 repertoires.Frontiers in immunology · 2026Article
- Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (Frontiers in immunology · 2026Article
- Immunoglobulin germline reference sequences enable investigations and reveal insights into bat-specific immunity.iScience · 2025Article
- Molecular Evolution of the NLR Gene Family Reveals Diverse Innate Immune Strategies in Bats.Biomolecules · 2025Article
- Translational lessons from the balanced immune system in bats.Disease models & mechanisms · 2025Review
- Different Species of Bats: Genomics, Transcriptome, and Immune Repertoire.Current issues in molecular biology · 2025Review
- Processing of genomic RNAs by Dicer in bat cells limits SARS-CoV-2 replication.Virology journal · 2025Article
- The Gut Microbiota of the Greater Horseshoe Bat Confers Rapidly Corresponding Immune Cells in Mice.Animals : an open access journal from MDPI · 2025Article
- Strategies and limitations of the bat immune response toFrontiers in immunology · 2025Review
- Review
- Disease tolerance as immune defense strategy in bats: One size fits all?PLoS pathogens · 2024Review
- Article
- A tale of endurance: bats, viruses and immune dynamics.Future microbiology · 2024Review
- Deciphering bat influenza H18N11 infection dynamics in male Jamaican fruit bats on a single-cell level.Nature communications · 2024Article
- Landscape of IGH germline genes of Chiroptera and the pattern ofMicrobiology spectrum · 2024Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBats are the natural reservoir host for a range of emerging and re-emerging viruses, including SARS-like coronaviruses, Ebola viruses, henipaviruses and Rabies viruses. However, the mechanisms responsible for the control of viral replication in bats are not understood and there is little information available on any aspect of antiviral immunity in bats. Massively parallel sequencing of the bat transcriptome provides the opportunity for rapid gene discovery. Although the genomes of one megabat and one microbat have now been sequenced to low coverage, no transcriptomic datasets have been reported from any bat species. In this study, we describe the immune transcriptome of the Australian flying fox, Pteropus alecto, providing an important resource for identification of genes involved in a range of activities including antiviral immunity.
resultsTowards understanding the adaptations that have allowed bats to coexist with viruses, we have de novo assembled transcriptome sequence from immune tissues and stimulated cells from P. alecto. We identified about 18,600 genes involved in a broad range of activities with the most highly expressed genes involved in cell growth and maintenance, enzyme activity, cellular components and metabolism and energy pathways. 3.5% of the bat transcribed genes corresponded to immune genes and a total of about 500 immune genes were identified, providing an overview of both innate and adaptive immunity. A small proportion of transcripts found no match with annotated sequences in any of the public databases and may represent bat-specific transcripts.
conclusionsThis study represents the first reported bat transcriptome dataset and provides a survey of expressed bat genes that complement existing bat genomic data. In addition, these data provide insight into genes relevant to the antiviral responses of bats, and form a basis for examining the roles of these molecules in immune response to viral infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.