ArticleJournal of the American Chemical Society2012
Nucleation effects in peptide foldamers.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Design and Synthesis of Novel Helix Mimetics Based on the Covalent H-Bond Replacement and Amide Surrogate.Molecules (Basel, Switzerland) · 2023Article
- Identification of Secondary Binding Sites on Protein Surfaces for Rational Elaboration of Synthetic Protein Mimics.ACS chemical biology · 2021Article
- Sulfono-γ-AApeptides as Helical Mimetics: Crystal Structures and Applications.Accounts of chemical research · 2020Article
- Macropinocytosis as a Key Determinant of Peptidomimetic Uptake in Cancer Cells.Journal of the American Chemical Society · 2020Article
- Covalent Targeting of Ras G12C by Rationally Designed Peptidomimetics.ACS chemical biology · 2020Article
- α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53-MDM2/MDMX Protein-Protein Interactions.Journal of medicinal chemistry · 2020Article
- Hydrogen Bond Surrogate Stabilization of β-Hairpins.ACS chemical biology · 2018Article
- Helix Propensities of Amino Acid Residues via Thioester Exchange.Journal of the American Chemical Society · 2017Article
- Review
- Modulating the Nucleated Self-Assembly of Tri-β(3) -Peptides Using Cucurbit[n]urils.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- Targeting recognition surfaces on natural proteins with peptidic foldamers.Current opinion in structural biology · 2016Review
- An optimal hydrogen-bond surrogate for α-helices.Chemical communications (Cambridge, England) · 2016Article
- α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells.Journal of the American Chemical Society · 2015Article
- Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.Angewandte Chemie (International ed. in English) · 2015Review
- Folding Thermodynamics of Protein-Like Oligomers with Heterogeneous Backbones.Chemical science · 2014Article
- Synthesis of hydrogen-bond surrogate α-helices as inhibitors of protein-protein interactions.Current protocols in chemical biology · 2014Article
- Effects of side chains in helix nucleation differ from helix propagation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Inhibition of α-helix-mediated protein-protein interactions using designed molecules.Nature chemistry · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Oligomers composed of β(3)-amino acid residues and a mixture of α- and β(3)-residues have emerged as proteolytically stable structural mimics of α-helices. An attractive feature of these oligomers is that they adopt defined conformations in short sequences. In this manuscript, we evaluate the impact of β(3)-residues as compared to their α-amino acid analogs in prenucleated helices. Our hydrogen-deuterium exchange results suggest that heterogeneous sequences composed of "αααβ" repeats are conformationally more rigid than the corresponding homogeneous α-peptide helices, with the macrocycle templating the helical conformation having a significant influence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.