ArticleEuropean journal of endocrinology2012
Plasma soluble α-klotho protein levels in premature and term neonates: correlations with growth and metabolic parameters.
Article in European journal of endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- KLOTHO Deficiency Drives Ovarian Aging by Inducing Granulosa Cell Senescence and Dysfunction.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Klotho as a novel biomarker of attention-deficit hyperactivity disorder and related executive dysfunction.BJPsych open · 2026Article
- Expression and clinical significance of Klotho protein in serum, umbilical cord blood, and placenta of pregnant women with intrauterine growth restriction.Frontiers in pediatrics · 2025Article
- Aging alters the expression of trophic factors and tight junction proteins in the mouse choroid plexus.Fluids and barriers of the CNS · 2024Article
- Regulation of trophic factors in the choroid plexus of aged mice.Research square · 2024Article
- Duration of Simultaneous Exposure to High-Risk and Lower-Risk Nephrotoxic Antimicrobials in the Neonatal Intensive Care Unit (NICU) and Future Adolescent Kidney Health.The Journal of pediatrics · 2024Article
- Composite Dietary Antioxidant Index and Plasma Levels of Soluble Klotho: Insights from NHANES.Oxidative medicine and cellular longevity · 2023Article
- Aging and antioxidants: the impact of dietary carotenoid intakes on soluble klotho levels in aged adults.Frontiers in endocrinology · 2023Article
- The potential therapeutic effect of klotho on cell viability in human colorectal adenocarcinoma HT-29 cells.Medical oncology (Northwood, London, England) · 2022Article
- Extrarenal expression of α-klotho, the kidney related longevity gene, in Heterocephalus glaber, the long living Naked Mole Rat.Scientific reports · 2021Article
- Advanced maternal age causes premature placental senescence and malformation via dysregulated α-Klotho expression in trophoblasts.Aging cell · 2021Article
- Lower urinary α-Klotho is associated with lower angiotensin-(1-7) and higher blood pressure in young adults born preterm with very low birthweight.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Cord blood klotho levels are inversely associated with leptin in healthy Latino neonates at risk for obesity.Journal of pediatric endocrinology & metabolism : JPEM · 2018Article
- Endothelin-1, α-Klotho, 25(OH) Vit D levels and severity of disease in scleroderma patients.Rheumatology international · 2017Article
- Klotho and fibroblast growth factor 23 in cerebrospinal fluid in children.Journal of bone and mineral metabolism · 2017Article
- Molecular basis of Klotho: from gene to function in aging.Endocrine reviews · 2015Review
- The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2015Article
- The anti-aging factor α-klotho during human pregnancy and its expression in pregnancies complicated by small-for-gestational-age neonates and/or preeclampsia.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2014Article
- Association between decreased klotho blood levels and organic growth hormone deficiency in children with growth impairment.PloS one · 2014Article
- Infection and smoking are associated with decreased plasma concentration of the anti-aging protein, α-klotho.Journal of perinatal medicine · 2013Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
objectiveα-Klotho (α-KL), a protein with antiaging properties, regulates phosphate, calcium, and bone metabolism, induces resistance to oxidative stress, and may participate in insulin signaling. The role of α-KL in neonates, known to be prone to metabolic disturbances and oxidative stress, is not known. The aim of this study was to evaluate circulating soluble α-KL concentrations in preterm and full-term neonates and unravel possible correlations with growth, metabolism, and indices of oxidative stress.
designProspective study.
methodsPlasma-soluble α-KL levels were determined by specific ELISA in 50 healthy neonates (25 preterm, mean (s.d.) gestational age (GA) 33.7 (1.1) weeks, and 25 full-term infants) at days 14 and 28 of life. Associations of α-KL with anthropometric, metabolic parameters, and indices of oxidative stress were examined.
resultsα-KL levels were significantly higher in full-term than in preterm infants at both days 14 (1099 (480) pg/ml vs 884 (239) pg/ml respectively; P<0.05) and 28 (1277 (444) pg/ml vs 983 (264) pg/ml respectively; P<0.01). In both preterm and full-term infants, α-KL levels increased significantly from day 14 to 28 of life (P<0.001). Circulating α-KL concentrations correlated with GA (β=0.32, P=0.001), body weight (β=0.34, P=0.001), body length (β=0.33, P=0.001), 1,25-dihydroxy-vitamin D level (β=0.24, P<0.05), and malondialdehyde level (β=0.20, P<0.05) but not with glucose, insulin, or homeostasis model assessment index of insulin resistance values.
conclusionsSoluble α-KL levels rise as GA and postnatal age advance in neonates and may have an impact on vitamin D metabolism and oxidative stress. Whether α-KL may have a role in the regulation of infants' growth should be further studied.
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