ArticlePloS one2012
A novel 5-enolpyruvylshikimate-3-phosphate synthase shows high glyphosate tolerance in Escherichia coli and tobacco plants.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 66 citations in OpenAlex.
- Breeding of glyphosate-tolerant genetically modified rice BriA15-38.GM crops & food · 2026Article
- A class II 5-enolpyruvylshikimate-3-phosphate synthase fromaBIOTECH · 2026Article
- Oxidative Stress, Phytochemical Screening, and Antioxidant Activity on Microalgae (Journal of xenobiotics · 2025Article
- Comparative metabolites analysis of resistant, susceptible and wild rice species in response to bacterial blight disease.BMC plant biology · 2025Article
- Highly EfficientPlants (Basel, Switzerland) · 2024Article
- In maize, co-expression of GAT and GR79-EPSPS provides high glyphosate resistance, along with low glyphosate residues.aBIOTECH · 2023Article
- Gastrointestinal Microbial Ecology of Weaned Piglets Fed Diets with Different Levels of Glyphosate.Microbiology spectrum · 2023Article
- Microbiomes and glyphosate biodegradation in edaphic and aquatic environments: recent issues and trends.World journal of microbiology & biotechnology · 2022Review
- Mild chronic exposure to pesticides alters physiological markers of honey bee health without perturbing the core gut microbiota.Scientific reports · 2022Article
- Inhibition of a nutritional endosymbiont by glyphosate abolishes mutualistic benefit on cuticle synthesis in Oryzaephilus surinamensis.Communications biology · 2021Article
- Overexpression of improved EPSPS gene results in field level glyphosate tolerance and higher grain yield in rice.Plant biotechnology journal · 2020Article
- Separating the Empirical Wheat From the Pseudoscientific Chaff: A Critical Review of the Literature Surrounding Glyphosate, Dysbiosis and Wheat-Sensitivity.Frontiers in microbiology · 2020Review
- Transgenic Cotton (Frontiers in plant science · 2020Article
- Expression patterns ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2019Article
- Glyphosate perturbs the gut microbiota of honey bees.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Expression of a bacterial aroA gene confers tolerance to glyphosate in tobacco plants.Turkish journal of biology = Turk biyoloji dergisi · 2018Article
- Article
- Genetically transformed tobacco plants expressing synthetic EPSPS gene confer tolerance against glyphosate herbicide.Physiology and molecular biology of plants : an international journal of functional plant biology · 2017Article
- Simultaneous Expression ofFrontiers in plant science · 2017Article
- Potential subchronic food safety of the stacked trait transgenic maize GH5112E-117C in Sprague-Dawley rats.Transgenic research · 2016Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A key enzyme in the shikimate pathway, 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) is the primary target of the broad-spectrum herbicide glyphosate. Identification of new aroA genes coding for EPSPS with a high level of glyphosate tolerance is essential for the development of glyphosate-tolerant crops. In the present study, the glyphosate tolerance of five bacterial aroA genes was evaluated in the E. coli aroA-defective strain ER2799 and in transgenic tobacco plants. All five aroA genes could complement the aroA-defective strain ER2799, and AM79 aroA showed the highest glyphosate tolerance. Although glyphosate treatment inhibited the growth of both WT and transgenic tobacco plants, transgenic plants expressing AM79 aroA tolerated higher concentration of glyphosate and had a higher fresh weight and survival rate than plants expressing other aroA genes. When treated with high concentration of glyphosate, lower shikimate content was detected in the leaves of transgenic plants expressing AM79 aroA than transgenic plants expressing other aroA genes. These results suggest that AM79 aroA could be a good candidate for the development of transgenic glyphosate-tolerant crops.
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