ArticleFrontiers in molecular neuroscience2012
Drug-evoked plasticity: do addictive drugs reopen a critical period of postnatal synaptic development?
Article in Frontiers in molecular neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Article
- Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens.Molecular psychiatry · 2022Review
- GluN3-Containing NMDA Receptors in the Rat Nucleus Accumbens Core Contribute to Incubation of Cocaine Craving.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The NMDA Receptor Subunit (GluN1 and GluN2A) Modulation Following Different Conditions of Cocaine Abstinence in Rat Brain Structures.Neurotoxicity research · 2021Article
- Drug-Evoked Synaptic Plasticity of Excitatory Transmission in the Ventral Tegmental Area.Cold Spring Harbor perspectives in medicine · 2021Review
- Activity-Based Anorexia Dynamically Dysregulates the Glutamatergic Synapse in the Nucleus Accumbens of Female Adolescent Rats.Nutrients · 2020Article
- Early Life Stress- and Drug-Induced Histone Modifications Within the Ventral Tegmental Area.Frontiers in cell and developmental biology · 2020Review
- The Molecular Basis of Drug Addiction: Linking Epigenetic to Synaptic and Circuit Mechanisms.Neuron · 2019Review
- Trafficking of calcium-permeable and calcium-impermeable AMPA receptors in nucleus accumbens medium spiny neurons co-cultured with prefrontal cortex neurons.Neuropharmacology · 2017Article
- Cocaine Promotes Coincidence Detection and Lowers Induction Threshold during Hebbian Associative Synaptic Potentiation in Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- SHANK3 controls maturation of social reward circuits in the VTA.Nature neuroscience · 2016Article
- Synaptic mechanisms underlying persistent cocaine craving.Nature reviews. Neuroscience · 2016Review
- Epac Signaling Is Required for Cocaine-Induced Change in AMPA Receptor Subunit Composition in the Ventral Tegmental Area.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- GluN2B-containing NMDA receptors blockade rescues bidirectional synaptic plasticity in the bed nucleus of the stria terminalis of cocaine self-administering rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Rapid, transient synaptic plasticity in addiction.Neuropharmacology · 2014Review
- Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction.Frontiers in cellular neuroscience · 2014Review
- Glutamatergic targets for new alcohol medications.Psychopharmacology · 2013Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As in other parts of the central nervous system (CNS) of the mouse, glutamatergic synapses onto dopamine (DA) neurons in the ventral tegmental area (VTA) mature postnatally. At birth many AMPA receptors (AMPARs) lack GluA2R subunit and most NMDARs contain the GluN2B subunit. Within 2 weeks these receptors are replaced with GluA2- and GluN2A- containing AMPARs and NMDARs, respectively. Recent data suggest that a single injection of cocaine (or another drug of addiction) triggers glutamate receptor redistribution with the reappearance of the subunits typically present in immature synapses, as if addictive drugs reopen the developmental critical period. Here we review the experimental evidence for this hypothesis and discuss the implications for circuit function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.