ArticleThe Plant cell2012
Gsp1 triggers the sexual developmental program including inheritance of chloroplast DNA and mitochondrial DNA in Chlamydomonas reinhardtii.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 60 citations in OpenAlex.
- Cytoplasmic inheritance: The transmission of plastid and mitochondrial genomes across cells and generations.Plant physiology · 2025Review
- The Expansion and Diversification of Epigenetic Regulatory Networks Underpins Major Transitions in the Evolution of Land Plants.Molecular biology and evolution · 2025Article
- Characteristics of NGenomics, proteomics & bioinformatics · 2023Article
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- Evolution of an assembly factor-based subunit contributed to a novel NDH-PSI supercomplex formation in chloroplasts.Nature communications · 2021Article
- Homeoprotein transduction in neurodevelopment and physiopathology.Science advances · 2020Review
- Step-wise elimination of α-mitochondrial nucleoids and mitochondrial structure as a basis for the strict uniparental inheritance in Cryptococcus neoformans.Scientific reports · 2020Article
- The molecular foundations of zygosis.Cellular and molecular life sciences : CMLS · 2020Review
- Common ancestry of heterodimerizing TALE homeobox transcription factors across Metazoa and Archaeplastida.BMC biology · 2018Article
- Gene Regulatory Networks for the Haploid-to-Diploid Transition ofPlant physiology · 2017Article
- Identification and Characterization of a cis-Regulatory Element for Zygotic Gene Expression in Chlamydomonas reinhardtii.G3 (Bethesda, Md.) · 2016Article
- Green algae and the origins of multicellularity in the plant kingdom.Cold Spring Harbor perspectives in biology · 2014Review
- Isolation and characterization of novel high-CO2-requiring mutants of Chlamydomonas reinhardtii.Photosynthesis research · 2014Article
- Cosuppression of RBCS3B in Arabidopsis leads to severe photoinhibition caused by ROS accumulation.Plant cell reports · 2014Article
- Origins of eukaryotic sexual reproduction.Cold Spring Harbor perspectives in biology · 2014Review
- Sex determination directs uniparental mitochondrial inheritance in Phycomyces.Eukaryotic cell · 2014Article
- Characterization of the inositol monophosphatase gene family in Arabidopsis.Frontiers in plant science · 2014Article
- Comparative genomics in Chlamydomonas and Plasmodium identifies an ancient nuclear envelope protein family essential for sexual reproduction in protists, fungi, plants, and vertebrates.Genes & development · 2013Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The isogamous green alga Chlamydomonas reinhardtii has emerged as a premier model for studying the genetic regulation of fertilization and sexual development. A key regulator is known to be a homeoprotein gene, GAMETE-SPECIFIC PLUS1 (GSP1), which triggers the zygotic program. In this study, we isolated a mutant, biparental31 (bp31), which lacks GSP1. bp31 mt+ gametes fuse normally to form zygotes, but the sexual development of the resulting diploid cell is arrested and pellicle/zygospore/tetrad formation is abolished. The uniparental inheritance of chloroplast (cp) and mitochondrial (mt) DNA (cytoplasmic inheritance) was also impaired. bp31 has a deletion of ∼60 kb on chromosome 2, including GSP1. The mutant phenotype was not rescued by transformation with GSP1 alone but could be rescued by the cotransformation with GSP1 and another gene, INOSITOL MONOPHOSPHATASE-LIKE1, which is involved in various cellular processes, including the phosphatidylinositol signaling pathway. This study confirms the importance of Gsp1 in mediating the zygotic program, including the uniparental inheritance of cp/mtDNA. Moreover, the results also suggest a role for inositol metabolism in the sexual developmental program.
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