ArticleMolecular biology reports2012
Molecular characterization of myostatin (MSTN) gene and association analysis with growth traits in the bighead carp (Aristichthys nobilis).
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- Functional Characterization of theGenes · 2023Article
- Characterisation of Single Nucleotide Polymorphisms and Haplotypes of MSTN Associated with Growth Traits in European Sea Bass (Dicentrarchus labrax).Marine biotechnology (New York, N.Y.) · 2023Article
- Exploring the influence of DNA methylation and single nucleotide polymorphisms of theFrontiers in genetics · 2023Article
- Effects of Dietary Paper MulberryAnimals : an open access journal from MDPI · 2021Article
- Article
- A first genetic linage map construction and QTL mapping for growth traits in Larimichthys polyactis.Scientific reports · 2020Article
- Association between expression levels and growth trait-related SNPs located in promoters of the MC4R and MSTN genes in Spinibarbus hollandi.Genes & genomics · 2018Article
- Generation of Myostatin Gene-Edited Channel Catfish (Ictalurus punctatus) via Zygote Injection of CRISPR/Cas9 System.Scientific reports · 2017Article
- cDNA sequence and protein bioinformatics analyses of MSTN in African catfish (Clarias gariepinus).Molecular biology reports · 2016Article
- Targeted disruption of sp7 and myostatin with CRISPR-Cas9 results in severe bone defects and more muscular cells in common carp.Scientific reports · 2016Article
- Integrative Transcriptome, Genome and Quantitative Trait Loci Resources Identify Single Nucleotide Polymorphisms in Candidate Genes for Growth Traits in Turbot.International journal of molecular sciences · 2016Article
- cDNA structure and the effect of fasting on myostatin expression in walking catfish (Clarias macrocephalus, Günther 1864).Fish physiology and biochemistry · 2015Article
- Novel single nucleotide polymorphisms of the insulin-like growth factor-I gene and their associations with growth traits in common carp (Cyprinus carpio L.).International journal of molecular sciences · 2014Article
- A SNP in the 5' flanking region of the myostatin-1b gene is associated with harvest traits in Atlantic salmon (Salmo salar).BMC genetics · 2013Article
- Development of molecular resources for an intertidal clam, Sinonovacula constricta, using 454 transcriptome sequencing.PloS one · 2013Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myostatin (MSTN) is a member of the transforming growth factor-β superfamily and functions as a negative regulator of skeletal muscle development and growth. In this study, the bighead carp MSTN gene (AnMSTN for short) was cloned and characterized. The 3,769 bp genomic sequence of AnMSTN consisted of three exons and two introns, and the full length cDNA (2,141 bp) of the gene had an open reading frame encoding a polypeptide of 375 amino acids. The deduced amino acid sequence of AnMSTN showed 67.1-98.7 % homology with MSTNs of avian, mammalian and teleostean species. Sequence comparison and phylogenetic analysis confirmed the MSTNs were conserved throughout the vertebrates and AnMSTN belonged to MSNT-1 isoform. AnMSTN was expressed in various tissues with the highest expression in muscle. Two single nucleotide polymorphisms, g.1668T > C in intron 2 and g.2770C > A in 3' UTR, were identified in AnMSTN by sequencing PCR fragments, and genotyped by SSCP. Association analysis showed that g.2770C > A genotypes were significantly associated with total length, body length and body weight (P < 0.01). These results suggest that AnMSTN involves in the regulation of growth, and this polymorphism would be informative for further studies on selective breeding in bighead carp.
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