ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2012
Sex-specific impact of prenatal stress on growth and reproductive parameters of guinea pigs.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Prenatal stress accelerates offspring growth to compensate for reduced maternal investment across mammals.Proceedings of the National Academy of Sciences of the United States of America · 2017Pooled it
- Metabolic rate and saliva cortisol concentrations in socially housed adolescent guinea pigs.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Fetal endocrine axes mRNA expression levels are related to sex and intrauterine position.Biology of sex differences · 2024Article
- Effect of Maternal Water Restriction on Sexual Behavior, Reproductive Performance, and Reproductive Hormones of Male Rat Offspring.Animals : an open access journal from MDPI · 2020Article
- Dietary fatty acids sex-specifically modulate guinea pig postnatal development via cortisol concentrations.Scientific reports · 2018Article
- Prenatal stress effects in a wild, long-lived primate: predictive adaptive responses in an unpredictable environment.Proceedings. Biological sciences · 2016Article
- Sex-specific prenatal stress effects on the rat reproductive axis and adrenal gland structure.Reproduction (Cambridge, England) · 2016Article
- Stress and Androgen Activity During Fetal Development.Endocrinology · 2015Review
- The maternal social environment shapes offspring growth, physiology, and behavioural phenotype in guinea pigs.Frontiers in zoology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Body condition and reproductive maturation are parameters of reproductive success that are influenced by sexual hormones rising in the circulation during the time of puberty. Various endocrine systems can be programmed by conditions experienced during early life. Stress for instance is supposed to be capable of influencing fetal development, leading to adjustments of offspring's later physiology. We examined whether prenatal stress (induced by exposure to strobe light) during early- to mid-gestation was capable of affecting later reproductive parameters in guinea pigs (Cavia aperea f. porcellus). Therefore, we measured the levels of testosterone and progesterone from the age of day 12-124 in prenatally stressed (PS, n = 20) and unaffected control animals (n = 24). Furthermore, we determined the timing of puberty and growth. Body weight development revealed significantly faster growth in PS females compared to control animals. The onset of first estrus was slightly earlier in PS females, however not significantly so. Cycle lengths and levels of progesterone differed between groups over the course of time with higher progesterone levels and more constant cycles among PS females compared to control females who displayed marked differences between first and subsequent cycles. Levels of testosterone did not differ between groups. We conclude that prenatal stress accelerates growth and maturity in females, but not in males.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.