ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2012
Surface modification counteracts adverse effects associated with immobilization after flexor tendon repair.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity.Nature biomedical engineering · 2022Article
- Risk factors of efficacy for patients receiving surgical treatment following terrible triad of the elbow joint: A comparative study.Medicine · 2019Article
- PXL01 in sodium hyaluronate results in increased PRG4 expression: a potential mechanism for anti-adhesion.Upsala journal of medical sciences · 2017Article
- Cell and Biologic-Based Treatment of Flexor Tendon Injuries.Operative techniques in orthopaedics · 2016Article
- Basic FGF or VEGF gene therapy corrects insufficiency in the intrinsic healing capacity of tendons.Scientific reports · 2016Article
- A comparative study of the effects of growth and differentiation factor 5 on muscle-derived stem cells and bone marrow stromal cells in an in vitro tendon healing model.The Journal of hand surgery · 2014Article
- CORR® ORS Richard A. Brand Award for Outstanding Orthopaedic Research: Engineering flexor tendon repair with lubricant, cells, and cytokines in a canine model.Clinical orthopaedics and related research · 2014Article
- Gliding resistance and modifications of gliding surface of tendon: clinical perspectives.Hand clinics · 2013Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Although post-rehabilitation is routinely performed following flexor tendon repair, in some clinical scenarios post-rehabilitation must be delayed. We investigated modification of the tendon surface using carbodiimide derivatized hyaluronic acid and lubricin (cd-HA-Lub) to maintain gliding function following flexor tendon repair with postoperative immobilization in a in vivo canine model. Flexor digitorum profundus tendons from the 2nd and 5th digits of one forepaw of six dogs were transected and repaired. One tendon in each paw was treated with cd-HA-Lub; the other repaired tendon was not treated. Following tendon repair, a forearm cast was applied to fully immobilize the operated forelimb for 10 days, after which the animals were euthanized. Digit normalized work of flexion (nWOF) and tendon gliding resistance were assessed. The nWOF of the FDP tendons treated with cd-HA-Lub was significantly lower than the nWOF of the untreated tendons (p < 0.01). The gliding resistance of cd-HA-Lub treated tendons was also significantly lower than that of the untreated tendons (p < 0.05). Surface treatment with cd-HA-Lub following flexor tendon repair provides an opportunity to improve outcomes for patients in whom the post-operative therapy must be delayed after flexor tendon repair.
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Registered trials
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