ReviewJournal of molecular medicine (Berlin, Germany)2012
Generating cells of the gastrointestinal system: current approaches and applications for the differentiation of human pluripotent stem cells.
Review in Journal of molecular medicine (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Stem cell-based tactics in the remodeling and treatment of intestinal diseases.Stem cell research & therapy · 2026Review
- Pancreatic gene expression during recovery after pancreatitis reveals unique transcriptome profiles.Scientific reports · 2018Article
- Stem cell-derived organoids to model gastrointestinal facets of cystic fibrosis.United European gastroenterology journal · 2017Review
- Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates.Cell stem cell · 2015Article
- In vivo reprogramming in inflammatory bowel disease.Gene therapy · 2013Review
- A gutsy task: generating intestinal tissue from human pluripotent stem cells.Digestive diseases and sciences · 2013Review
- Modelling human disease with pluripotent stem cells.Current gene therapy · 2013Review
- Aldh1-expressing endocrine progenitor cells regulate secondary islet formation in larval zebrafish pancreas.PloS one · 2013Article
- Stem cell biology--from basic research to regenerative medicine.Journal of molecular medicine (Berlin, Germany) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human pluripotent stem cells (hPSCs), including human embryonic stem cells and induced pluripotent stem cells, are defined by their abilities to self-renew and to differentiate into any cell type of the human body. Due to these unique properties, hPSCs represent a potentially unlimited source of cells/tissues for cell replacement therapies. Use of these cells may also revolutionize the way drugs are discovered, designed, and tested. Furthermore, the study of how cells differentiate can also change our understanding of complex human biology and disease. For these reasons, scientists have dedicated significant time and effort to generate specific cell types from hPSCs with therapeutic potential, including cells derived from the definitive endoderm germ layer such as liver cells (hepatocytes) and pancreatic β cells. In this review, we will focus broadly on the most advanced differentiation strategies currently employed to differentiate hPSCs to endodermal lineages such as the liver, pancreas, and intestine as well as the principles of developmental biology around which these protocols were designed. This will be followed by a brief discussion of the vast potential of these systems as suitable in vitro models for human embryonic development and disease.
Indexed as
Identifiers
22714642What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.