ArticleSmall GTPases
Regulation of the mTOR-Rac1 axis in platelet function.
Article in Small GTPases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 23 citations in OpenAlex.
- Co-expression analysis to identify key modules and hub genes associated with COVID-19 in platelets.BMC medical genomics · 2022Article
- mTOR regulates GPVI-mediated platelet activation.Journal of translational medicine · 2021Article
- Rapamycin in ischemic stroke: Old drug, new tricks?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Review
- Protein kinase C and P2Y12 take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets.Journal of thrombosis and haemostasis : JTH · 2014Article
- p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
- Rho GTPases in platelet function.Journal of thrombosis and haemostasis : JTH · 2013Review
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2 authors at 2 institutions in 1 country.
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Abstract
Small GTPase proteins regulate cytoskeletal dynamics to orchestrate diverse cellular functions in organismal physiology, development and disease. The Rho GTPase family member Rac1 is central to actin-driven processes in a number of cell types, particularly platelets, where Rac1 serves as an essential mediator of lamellipodia formation and thrombus stability. Despite the importance of Rac1 to platelet function, little is known about how Rac1 activity is regulated in platelets. We recently defined the tyrosine-kinase based signaling cascade that activates mTOR to regulate Rac1 activation downstream of platelet integrin and glycoprotein receptors. We demonstrated a critical role for the mTOR-Rac1 axis in regulating platelet spreading, aggregation and aggregate stability under shear. These studies suggest that in addition to cancer and transplant medicine, intervention of the mTOR system may have implications for hemostatic and thrombotic processes as well as immunotherapies and intravascular stent design.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.