ArticleSmall GTPases
The taming of a Rab GTPase by Legionella pneumophila.
Article in Small GTPases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Multi-tiered actions ofeLife · 2024Article
- AtypicalScience advances · 2022Article
- Translocated Legionella pneumophila small RNAs mimic eukaryotic microRNAs targeting the host immune response.Nature communications · 2022Article
- Non-canonical activation of the ER stress sensor ATF6 byLife science alliance · 2021Article
- The unity of opposites: Strategic interplay between bacterial effectors to regulate cellular homeostasis.The Journal of biological chemistry · 2021Review
- Structural and functional study of Legionella pneumophila effector RavA.Protein science : a publication of the Protein Society · 2021Article
- Review
- Article
- Hostile Takeover: Hijacking of Endoplasmic Reticulum Function by T4SS and T3SS Effectors Creates a Niche for Intracellular Pathogens.Microbiology spectrum · 2019Article
- Strategies Used by Bacteria to Grow in Macrophages.Microbiology spectrum · 2016Review
- Review
- Targeting of host organelles by pathogenic bacteria: a sophisticated subversion strategy.Nature reviews. Microbiology · 2016Review
- Inhibition of host cell translation elongation by Legionella pneumophila blocks the host cell unfolded protein response.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Legionella suppresses the host unfolded protein response via multiple mechanisms.Nature communications · 2015Article
- Host-pathogen interaction profiling using self-assembling human protein arrays.Journal of proteome research · 2015Article
- Structural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM.Structure (London, England : 1993) · 2014Article
- Identification of Legionella pneumophila effectors regulated by the LetAS-RsmYZ-CsrA regulatory cascade, many of which modulate vesicular trafficking.Journal of bacteriology · 2014Article
- Maintenance of vacuole integrity by bacterial pathogens.Current opinion in microbiology · 2014Review
- Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.PLoS biology · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Small GTPases of the Rab family represent an attractive target for microbial pathogens due to their role in controlling many aspects of intracellular cargo transport. Legionella pneumophila is an intravacuolar pathogen that survives inside host cells by manipulating protein trafficking pathways through a number of effector proteins secreted by the bacterium. These act as functional mimics of host proteins that modulate the activity of switch proteins such as guanosine triphosphatases (GTPases). L. pneumophila exploits the ER (endoplasmic reticulum)-to-Golgi vesicle transport pathway by modifying activity of Rab1, the GTPase regulating this pathway. This pathogen recruits Rab1 to the vacuole in which it resides, where effector proteins located on the surface of the vacuole regulate the activity status of Rab1 by mimicking the function of a guanine dissociation inhibitor (GDI) displacement factor, guanine exchange factor (GEF), or a GTPase-activating protein (GAP). In addition to these non-covalent modifications that alter the nucleotide binding state of Rab1, the bacterium also uses covalent modifications such as adenylylation (AMPylation) to control the dynamic of Rab1 on the Legionella-containing vacuole. Remarkably, AMPylation of Rab1 by SidM can be reversed by the L. pneumophila effector protein SidD, which exhibits de-AMPylation activity, demonstrating that L. pneumophila and related pathogens may utilize covalent modifications in order to transiently alter the activity of host proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.