ArticleGenetics2012
Activity-dependent A-to-I RNA editing in rat cortical neurons.
Article in Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- A Systematic Review of Common and Brain-Disease-Specific RNA Editing Alterations Providing Novel Insights into Neurological and Neurodegenerative Disease Manifestations.Biomolecules · 2022Pooled it
- Spatiotemporal and genetic regulation of A-to-I editing throughout human brain development.Cell reports · 2022Article
- RNA editing of ion channels and receptors in physiology and neurological disorders.Oxford open neuroscience · 2022Review
- Application of Induced Pluripotent Stem Cell-Derived Models for Investigating microRNA Regulation in Developmental Processes.Frontiers in genetics · 2022Review
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission.Journal of neurochemistry · 2021Article
- Long-term maturation of human cortical organoids matches key early postnatal transitions.Nature neuroscience · 2021Article
- Circadian Regulation of GluA2 mRNA Processing in the Rat Suprachiasmatic Nucleus and Other Brain Structures.Molecular neurobiology · 2021Article
- Pre-reproductive stress and fluoxetine treatment in rats affect offspring A-to-I RNA editing, gene expression and social behavior.Environmental epigenetics · 2018Article
- A-to-I RNA editing in the rat brain is age-dependent, region-specific and sensitive to environmental stress across generations.BMC genomics · 2018Article
- The Good and the Bad of Glutamate Receptor RNA Editing.Molecular neurobiology · 2017Review
- R/G editing in GluA2RScientific reports · 2017Article
- Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity.Cell reports · 2017Article
- Interfacing Neural Network Components and Nucleic Acids.Frontiers in bioengineering and biotechnology · 2017Review
- Dynamic regulation of RNA editing in human brain development and disease.Nature neuroscience · 2016Article
- Adenosine to Inosine editing frequency controlled by splicing efficiency.Nucleic acids research · 2016Article
- Transcriptomics analysis of iPSC-derived neurons and modeling of neuropsychiatric disorders.Molecular and cellular neurosciences · 2016Review
- Epigenetics in NG2 glia cells.Brain research · 2016Review
- Enhanced long term potentiation and decreased AMPA receptor desensitization in the acute period following a single kainate induced early life seizure.Neurobiology of disease · 2016Article
- Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer's disease.RNA (New York, N.Y.) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Changes in neural activity influence synaptic plasticity/scaling, gene expression, and epigenetic modifications. We present the first evidence that short-term and persistent changes in neural activity can alter adenosine-to-inosine (A-to-I) RNA editing, a post-transcriptional site-specific modification found in several neuron-specific transcripts. In rat cortical neuron cultures, activity-dependent changes in A-to-I RNA editing in coding exons are present after 6 hr of high potassium depolarization but not after 1 hr and require calcium entry into neurons. When treatments are extended from hours to days, we observe a negative feedback phenomenon: Chronic depolarization increases editing at many sites and chronic silencing decreases editing. We present several different modulations of neural activity that change the expression of different mRNA isoforms through editing.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.