ArticleMedical oncology (Northwood, London, England)2012
The expression and prognosis of FOXO3a and Skp2 in human ovarian cancer.
Article in Medical oncology (Northwood, London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Progress of targeted FOX family therapy in ovarian cancer.Frontiers in pharmacology · 2025Review
- LncRNAs as nodes for the cross-talk between autophagy and Wnt signaling in pancreatic cancer drug resistance.International journal of biological sciences · 2024Review
- Article
- Role of circ-FOXO3 and miR-23a in radiosensitivity of breast cancer.Breast cancer (Tokyo, Japan) · 2023Article
- Circular RNA Foxo3: A Promising Cancer-Associated Biomarker.Frontiers in genetics · 2021Review
- Acetylshikonin Induces Apoptosis in Human Colorectal Cancer HCT-15 and LoVo Cells via Nuclear Translocation of FOXO3 and ROS Level Elevation.Oxidative medicine and cellular longevity · 2021Article
- miR-590-3p Targets Cyclin G2 and FOXO3 to Promote Ovarian Cancer Cell Proliferation, Invasion, and Spheroid Formation.International journal of molecular sciences · 2019Article
- A positive feed-forward loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma.Molecular cancer · 2019Article
- Expression of FOXP1 and FOXO3a in extrahepatic cholangiocarcinoma and the implications in clinicopathological significance and prognosis.OncoTargets and therapy · 2019Article
- Critical role of FOXO3a in carcinogenesis.Molecular cancer · 2018Review
- Mitoxantrone induces apoptosis in osteosarcoma cells through regulation of the Akt/FOXO3 pathway.Oncology letters · 2018Article
- Expression of PIM-1 in salivary gland adenoid cystic carcinoma: Association with tumor progression and patients' prognosis.Oncology letters · 2018Article
- Nitidine chloride inhibited the expression of S phase kinase-associated protein 2 in ovarian cancer cells.Cell cycle (Georgetown, Tex.) · 2017Article
- Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity.Oncology letters · 2017Article
- High Skp2/Low p57(Kip2) Expression is Associated with Poor Prognosis in Human Breast Carcinoma.Breast cancer : basic and clinical research · 2015Article
- Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53.International journal of oncology · 2014Article
- Article
- ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of Rab7.Cell death and differentiation · 2014Article
- Lycopene and beta-carotene induce growth inhibition and proapoptotic effects on ACTH-secreting pituitary adenoma cells.PloS one · 2013Article
- Skp2 and its emerging role in the pathogenesis of systemic malignancies besides breast carcinomas.Frontiers in oncology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The forkhead box proteins (FOXO proteins) comprise a large family of functionally diverse transcription factors involved in cellular proliferation, transformation, differentiation and longevity. Recently, ubiquitination and proteasome degradation of FOXO3a have been reported. In this study, we investigated the role of FOXO3a and Skp2 in human ovarian cancer. We detected the expression of FOXO3a and Skp2 in ovarian cancer by immunohistochemistry (IHC) and analyzed the relationship of FOXO3a and Skp2 with clinicopathological parameters, including prognosis. Immunohistochemical analysis was performed on formalin-fixed paraffin sections of 46 specimens in vivo. We found that the expression of FOXO3a was negatively related to Skp2 expression (r = -0.743; p < 0.05) and FOXO3a expression correlates significantly with disease stage (p = 0.007) and lymph node (p = 0.009) while Skp2 expression correlates significantly with age (p = 0.040), disease stage (p = 0.003) and lymph node (p = 0.019). Kaplan-Meier analysis revealed that survival curves of low versus high expressers of FOXO3a and Skp2 showed a highly significant separation in ovarian cancer (p < 0.01). FOXO3a and Skp2 may be considered to be important prognoses in human ovarian cancer.
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