ArticleMolecular and cellular endocrinology2012
The role for runt related transcription factor 2 (RUNX2) as a transcriptional repressor in luteinizing granulosa cells.
Article in Molecular and cellular endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- PGR-mediated transcriptome identifies SOX9 as a critical regulator of progesterone production in human ovulatory follicles.iScience · 2026Article
- CCAAT/Enhancer-Binding Proteins α and β Regulate Ovulation and Gene Expression via Dose- and Stage-Dependent Mechanisms.Endocrinology · 2025Article
- New insights into the ovulatory process in the human ovary.Human reproduction update · 2025Review
- Progesterone receptor mediates ovulatory transcription through RUNX transcription factor interactions and chromatin remodelling.Nucleic acids research · 2023Article
- A single-cell gene expression atlas of human follicular aspirates: Identification of leukocyte subpopulations and their paracrine factors.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Role of Runx2 in prostate development and stem cell function.The Prostate · 2021Article
- Core Binding Factors are essential for ovulation, luteinization, and female fertility in mice.Scientific reports · 2020Article
- RUNX3 Promotes the Tumorigenic Phenotype in KGN, a Human Granulosa Cell Tumor-Derived Cell Line.International journal of molecular sciences · 2019Article
- Ovulation: Parallels With Inflammatory Processes.Endocrine reviews · 2019Review
- Ablation of Runx2 in Ameloblasts Suppresses Enamel Maturation in Tooth Development.Scientific reports · 2018Article
- Core Binding Factor β Expression in Ovarian Granulosa Cells Is Essential for Female Fertility.Endocrinology · 2018Article
- Core Binding Factor-β Knockdown Alters Ovarian Gene Expression and Function in the Mouse.Molecular endocrinology (Baltimore, Md.) · 2016Article
- Article
- Characterization of the Runx gene family in a jawless vertebrate, the Japanese lamprey (Lethenteron japonicum).PloS one · 2014Article
- Expression of mesenchymal stem cells-related genes and plasticity of aspirated follicular cells obtained from infertile women.BioMed research international · 2014Article
- Plasticity of granulosa cells: on the crossroad of stemness and transdifferentiation potential.Journal of assisted reproduction and genetics · 2013Review
- Detection of RUNX2 gene expression in cumulus cells in women undergoing controlled ovarian stimulation.Reproductive biology and endocrinology : RB&E · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Transcription factors induced by the LH surge play a vital role in reprogramming the gene expression in periovulatory follicles. The present study investigated the role of RUNX2 transcription factor in regulating the expression of Runx1, Ptgs2, and Tnfaip6 using cultured granulosa cells isolated from PMSG-primed immature rats. hCG or forskolin+PMA induced the transient increase in Runx1, Ptgs2, and Tnfaip6 expression, while the expression of Runx2 continued to increase until 48 h. The knockdown of the agonist-stimulated Runx2 expression increased Runx1, Ptgs2, and Tnfaip6 expression and PGE(2) levels in luteinizing granulosa cells. Conversely, the over-expression of RUNX2 inhibited the expression of these genes and PGE(2) levels. The mutation of RUNX binding motifs in the Runx1 promoter enhanced transcriptional activity of the Runx1 promoter. The knockdown and overexpression of Runx2 increased and decreased Runx1 promoter activity, respectively. ChIP assays revealed the binding of RUNX2 in the Runx1 and Ptgs2 promoters. Together, these novel findings provide support for the role of RUNX2 in down-regulation of Runx1, Ptgs2, and Tnfaip6 during the late ovulatory period to support proper ovulation and/or luteinization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.