Trial reportEuropean journal of clinical nutrition2012
Urinary estrogen metabolites in two soy trials with premenopausal women.
Trial report in European journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of the Intake of Isoflavones on Risk Factors of Breast Cancer-A Systematic Review of Randomized Controlled Intervention Studies.Nutrients · 2021Pooled it
- Pooled it
- Soy Food Intake and Biomarkers of Breast Cancer Risk: Possible Difference in Asian Women?Nutrition and cancer · 2017Trial
- Oestrogen levels in serum and urine of premenopausal women eating low and high amounts of meat.Public health nutrition · 2014Trial
- Urinary isoflavonoid excretion as a biomarker of dietary soy intake during two randomized soy trials.Asia Pacific journal of clinical nutrition · 2014Trial
- The Impacts of Genistein and Daidzein on Estrogen Conjugations in Human Breast Cancer Cells: A Targeted Metabolomics Approach.Frontiers in pharmacology · 2017Article
- Plasma equol concentration is not associated with breast cancer and fibrocystic breast conditions among women in Shanghai, China.Nutrition research (New York, N.Y.) · 2016Article
- Association of estrogen measurements in serum and urine of premenopausal women.Biomarkers in medicine · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundSoy consumption may protect against breast cancer through modification of estrogen metabolism.
objectivesWe examined the effect of soy foods on urinary estrogens and the 2-hydroxy (OH)/16α-OH estrone (E(1)) ratio in two dietary interventions with premenopausal women. SUBJECTS/
methodsThe Breast, Estrogens, And Nutrition (BEAN1) study was a 2-year randomized trial and BEAN2 a 13-month randomized crossover study. In both interventions, study participants consumed a high-soy diet with 2 soy food servings/day and a low-soy diet with <3 servings of soy/week. Urine samples were collected at baseline and at the end of the diet periods, analyzed for nine estrogen metabolites by liquid chromatography mass spectrometry, and adjusted for creatinine levels. For BEAN1, two samples for 188 participants and for BEAN2, three samples for 79 women were analyzed. We applied mixed-effects regression models with log-transformed values of estrogen metabolites and soy intake as the exposure variable.
resultsIn BEAN1, no effect of the high-soy diet on individual estrogen metabolites or hydroxylation pathways was observed. The median 2-OH/16α-OHE(1) ratio decreased non-significantly in the intervention group from 6.2 to 5.2 as compared with 6.8 and 7.2 in the control group (P=0.63). In BEAN2, only 4-OHE(1) was significantly lower after the high-soy diet. Interaction terms of the high-soy diet with equol producer status, ethnicity and weight status revealed no significant effect modification.
conclusionsContrary to our hypothesis and some previous reports, the results from two well-controlled dietary interventions do not support an effect of a high-soy diet on a panel of urinary estrogen metabolites and the 2-OH/16α-OHE(1) ratio.
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