ArticleNature communications2012
Neuronal influence on peripheral circadian oscillators in pupal Drosophila prothoracic glands.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Comprehensive transcriptomics comparison reveals switch of gene networks in the brain during silkworm domestication.Insect science · 2026Article
- Tissue-specific CLOCK isoforms modulate circadian feedback loops to govern reproductive fitness in Drosophila.Cellular and molecular life sciences : CMLS · 2025Article
- Timed receptor tyrosine kinase signaling couples the central and a peripheral circadian clock inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Roles of peripheral clocks: lessons from the fly.FEBS letters · 2022Review
- Transcriptional Regulators of Ecdysteroid Biosynthetic Enzymes and Their Roles in Insect Development.Frontiers in physiology · 2022Review
- Reciprocal Relationship Between Calcium Signaling and Circadian Clocks: Implications for Calcium Homeostasis, Clock Function, and Therapeutics.Frontiers in molecular neuroscience · 2021Review
- The Development and Decay of the Circadian Clock inClocks & sleep · 2019Review
- Transcriptomic analysis of the prothoracic gland from two lepidopteran insects, domesticated silkmoth Bombyx mori and wild silkmoth Antheraea pernyi.Scientific reports · 2019Article
- Nighttime activities and peripheral clock oscillations depend on Wolbachia endosymbionts in flies.Scientific reports · 2018Article
- Calcium and cAMP directly modulate the speed of the Drosophila circadian clock.PLoS genetics · 2018Article
- Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila.Nature communications · 2017Article
- Circadian Rhythms and Sleep inGenetics · 2017Review
- Regulation of molecular clock oscillations and phagocytic activity via muscarinic CaScientific reports · 2017Article
- The Insect Prothoracic Gland as a Model for Steroid Hormone Biosynthesis and Regulation.Cell reports · 2016Article
- Transcriptional regulation of insect steroid hormone biosynthesis and its role in controlling timing of molting and metamorphosis.Development, growth & differentiation · 2016Review
- Heterogeneity of the Peripheral Circadian Systems in Drosophila melanogaster: A Review.Frontiers in physiology · 2016Review
- Bmal1 is an essential regulator for circadian cytosolic Ca²⁺ rhythms in suprachiasmatic nucleus neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Serotonin-2C receptor involved serotonin-induced Ca²⁺ mobilisations in neuronal progenitors and neurons in rat suprachiasmatic nucleus.Scientific reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rhythmic expression of period (per) and timeless (tim) genes in central circadian pacemaker neurons and prothoracic gland cells, part of the peripheral circadian oscillators in flies, may synergistically control eclosion rhythms, but their oscillatory profiles remain unclear. Here we show differences and interactions between peripheral and central oscillators using per-luciferase and cytosolic Ca(2+) reporter (yellow cameleon) imaging in organotypic prothoracic gland cultures with or without the associated central nervous system. Isolated prothoracic gland cells exhibit light-insensitive synchronous per-transcriptional rhythms. In prothoracic gland cells associated with the central nervous system, however, per transcription is markedly amplified following 12-h light exposure, resulting in the manifestation of day-night rhythms in nuclear PER immunostaining levels and spontaneous Ca(2+) spiking. Unlike PER expression, nuclear TIM expression is associated with day-night cycles that are independent of the central nervous system. These results demonstrate that photoreception and synaptic signal transduction in/from the central nervous system coordinate molecular 'gears' in endocrine oscillators to generate physiological rhythms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.