Evidence map›Paper›PMID 22713745›Full record

ReviewMicrobes and infection2012

Animal models to study the pathogenesis of enterotoxigenic Clostridium perfringens infections.

Francisco A Uzal, Bruce A McClane

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Microbes and infection, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Microorganisms · 2025
    Article
  2. The biology and pathogenicity ofMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Francisco A UzalCalifornia Animal Health and Food Safety Laboratory System, San Bernardino Branch, School of Veterinary Medicine, University of California, Davis, San Bernardino, CA 92408, USA. fuzal@cahfs.ucdavis.edu
Bruce A McClane
University of California, Davis · USUniversity of Pittsburgh · US

Funding

Mechanisms of Action of C. Perfringens EnterotoxinR37AI019844 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MC CLANE, BRUCE A · 2005 to 2014
$3.0M
NIAID NIH HHS R37 AI019844NIAID NIH HHS R37 AI019844-29
6 · The paper itself

Abstract

Rabbits, mice, rats, non-human primates, sheep and cattle have been used to study the effect of Clostridium perfringens enterotoxin (CPE). CPE produces mostly necrosis of the small intestinal epithelium along with fluid accumulation in rabbits and mice. In the latter, CPE can bind to internal organs such as the liver, which induces lethal potassium levels in blood.

Indexed as

Disease Models, AnimalAnimalsCattleClostridium InfectionsClostridium perfringensEnterotoxinsHumansIntestinal MucosaIntestine, SmallMicePotassiumPrimatesRabbitsRatsSheepVirulence Factorsenterotoxin, ClostridiumEnterotoxinsPotassiumVirulence Factors

Identifiers

PMID22713745
PMCPMC3572749
OpenAlexW2015634343

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.