ArticleBiophysical journal2012
Phase separation and fluctuations in mixtures of a saturated and an unsaturated phospholipid.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 53 citations in OpenAlex.
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- Understanding the free-energy landscape of phase separation in lipid bilayers using molecular dynamics.Biophysical journal · 2023Article
- Understanding the Free Energy Landscape of Phase Separation in Lipid Bilayers using Molecular Dynamics.bioRxiv : the preprint server for biology · 2023Article
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- Lipid packing is disrupted in copolymeric nanodiscs compared with intact membranes.Biophysical journal · 2023Article
- Membrane thickness, lipid phase and sterol type are determining factors in the permeability of membranes to small solutes.Nature communications · 2022Article
- Partitioning of a Hybrid Lipid in Domains of Saturated and Unsaturated Lipids in a Model Cellular Membrane.ACS omega · 2021Article
- Biophysical parameters of the Sec14 phospholipid exchange cycle - Effect of lipid packing in membranes.Biochimica et biophysica acta. Biomembranes · 2021Article
- Structural Characterization of Natural Yeast Phosphatidylcholine and Bacterial Phosphatidylglycerol Lipid Multilayers by Neutron Diffraction.Frontiers in chemistry · 2021Article
- Molecular Sensing with Host Systems for HyperpolarizedMolecules (Basel, Switzerland) · 2020Review
- Exploring the Dual Interaction of Natural Rhamnolipids with Plant and Fungal Biomimetic Plasma Membranes through Biophysical Studies.International journal of molecular sciences · 2019Article
- Subnanometer Structure of an Asymmetric Model Membrane: Interleaflet Coupling Influences Domain Properties.Langmuir : the ACS journal of surfaces and colloids · 2016Article
- GUVs melt like LUVs: the large heat capacity of MLVs is not due to large size or small curvature.Biophysical journal · 2015Article
- A Permeability Study of O2 and the Trace Amine p-Tyramine through Model Phosphatidylcholine Bilayers.PloS one · 2015Article
- Eliminating the roughness in cholesterol's β-face: does it matter?Langmuir : the ACS journal of surfaces and colloids · 2014Article
- A retained secretory signal peptide mediates high density lipoprotein (HDL) assembly and function of haptoglobin-related protein.The Journal of biological chemistry · 2014Article
- Depolarization Laplace transform analysis of exchangeable hyperpolarized ¹²⁹Xe for detecting ordering phases and cholesterol content of biomembrane models.Biophysical journal · 2014Article
- Statistical analysis of peptide-induced graded and all-or-none fluxes in giant vesicles.Biophysical journal · 2013Article
- Sorting of lipidated peptides in fluid bilayers: a molecular-level investigation.Journal of the American Chemical Society · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe quantitatively the interactions in a mixture of a saturated and an unsaturated phospholipid, and their consequences to the phase behavior at macroscopic and microscopic levels. This type of lipid-lipid interaction is fundamental in determining the organization and physical behavior of biological membranes. Mixtures of dipalmitoylphosphatidylcholine (DPPC) and 1-palmitoyl-2-oleoylphosphatidylcholine (POPC) are examined in detail by multiple experimental approaches (differential scanning calorimetry (DSC), fluorescence resonance energy transfer, and confocal fluorescence microscopy) in combination with Monte Carlo simulations in a lattice. The interactions between all possible pairs of lipid species and states are determined by matching the heat capacity calculated through Monte Carlo simulations to that measured experimentally by DSC. Only for one other lipid system, a mixture between two saturated phosphatidylcholines, is a similar quantitative description available. The interactions in the two systems and different representations used to model them are compared. Phase separation occurs in DPPC/POPC at about the center of the phase diagram mapped by DSC, but not at all compositions and temperatures in the coexistence region. Close to the extremes of composition, the phase behavior is best described by large fluctuations. At the heat capacity maxima in the mixtures, the domain size distributions change remarkably; large domains disappear and cooperative fluctuations increase.
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