ArticleBiophysical journal2012
Stochastic 16-state model of voltage gating of gap-junction channels enclosing fast and slow gates.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Gap Junction Channel Regulation: A Tale of Two Gates-Voltage Sensitivity of the Chemical Gate and Chemical Sensitivity of the Fast Voltage Gate.International journal of molecular sciences · 2024Review
- Modeling and analysis of voltage gating of gap junction channels at a single-channel level.Biophysical journal · 2023Article
- Four-State Model for Simulating Kinetic and Steady-State Voltage-Dependent Gating of Gap Junctions.Biophysical journal · 2020Article
- Inner Ear Connexin Channels: Roles in Development and Maintenance of Cochlear Function.Cold Spring Harbor perspectives in medicine · 2019Review
- Properties of cardiac conduction in a cell-based computational model.PLoS computational biology · 2019Article
- Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.Pharmacological reviews · 2017Review
- Functional asymmetry and plasticity of electrical synapses interconnecting neurons through a 36-state model of gap junction channel gating.PLoS computational biology · 2017Article
- Stochastic Model of Gap Junctions Exhibiting Rectification and Multiple Closed States of Slow Gates.Biophysical journal · 2016Article
- Reverberation of excitation in neuronal networks interconnected through voltage-gated gap junction channels.The Journal of general physiology · 2016Article
- A unified framework for spiking and gap-junction interactions in distributed neuronal network simulations.Frontiers in neuroinformatics · 2015Article
- Computational Approaches to Understanding the Role of Fibroblast-Myocyte Interactions in Cardiac Arrhythmogenesis.BioMed research international · 2015Review
- Application of stochastic automata networks for creation of continuous time Markov chain models of voltage gating of gap junction channels.BioMed research international · 2015Article
- Functional effects of Cx50 mutations associated with congenital cataracts.American journal of physiology. Cell physiology · 2014Article
- The D50N mutation and syndromic deafness: altered Cx26 hemichannel properties caused by effects on the pore and intersubunit interactions.The Journal of general physiology · 2013Article
- Regulation of connexin36 gap junction channels by n-alkanols and arachidonic acid.The Journal of physiology · 2013Article
- Intracellular magnesium-dependent modulation of gap junction channels formed by neuronal connexin36.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Learning theories reveal loss of pancreatic electrical connectivity in diabetes as an adaptive response.PloS one · 2013Article
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4 authors.
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Abstract
Gap-junction (GJ) channels formed of connexin (Cx) proteins provide a direct pathway for electrical and metabolic cell-cell interaction. Each hemichannel in the GJ channel contains fast and slow gates that are sensitive to transjunctional voltage (Vj). We developed a stochastic 16-state model (S16SM) that details the operation of two fast and two slow gates in series to describe the gating properties of homotypic and heterotypic GJ channels. The operation of each gate depends on the fraction of Vj that falls across the gate (VG), which varies depending on the states of three other gates in series, as well as on parameters of the fast and slow gates characterizing 1), the steepness of each gate's open probability on VG; 2), the voltage at which the open probability of each gate equals 0.5; 3), the gating polarity; and 4), the unitary conductances of the gates and their rectification depending on VG. S16SM allows for the simulation of junctional current dynamics and the dependence of steady-state junctional conductance (gj,ss) on Vj. We combined global coordinate optimization algorithms with S16SM to evaluate the gating parameters of fast and slow gates from experimentally measured gj,ss-Vj dependencies in cells expressing different Cx isoforms and forming homotypic and/or heterotypic GJ channels.
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