ReviewSeminars in perinatology2012
Obesity and the risk and detection of fetal malformations.
Review in Seminars in perinatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pannus Retraction for Ultrasound Evaluation of the Obese Gravida: A Pilot Study
Pannus Assistance Needed for Obstetric Ultrasound Studies: A Randomized Controlled Trial
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Maternal obesity in Africa: a systematic review and meta-analysis.Journal of public health (Oxford, England) · 2016Pooled it
- Association of obstetrics and foetal ultrasound parameters with maternal serum Lamin A: A teaching institution-based cross-sectional study.Journal of family medicine and primary care · 2026Article
- Associations of maternal and paternal characteristics with cardiac malformations using real-world data and machine learning.Communications medicine · 2025Article
- Effect of Obesity on Aquaporin5 Expression in Human Placental and Uterus Tissues.Journal of clinical medicine · 2024Article
- Article
- Influence of Parental Exposure to Risk Factors in the Occurrence of Oral Clefts.Journal of dentistry (Shiraz, Iran) · 2020Article
- Maternal Overweight, Inflammation and Neurological Consequences for the Preterm Child: Results of the ELGAN Study.Geburtshilfe und Frauenheilkunde · 2019Article
- Pregnancy after bariatric surgery: a narrative literature review and discussion of impact on pregnancy management and outcome.BMC pregnancy and childbirth · 2018Review
- Neuroanatomical Framework of the Metabolic Control of Reproduction.Physiological reviews · 2018Review
- Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome.Endocrinology · 2018Article
- A parental perspective concerning barriers to care for neural tube defects in China.Surgical neurology international · 2017Article
- Clinical management of pregnancy in the obese mother: before conception, during pregnancy, and post partum.The lancet. Diabetes & endocrinology · 2016Review
- The relevance of the Renin-Angiotensin system in the development of drugs to combat preeclampsia.International journal of endocrinology · 2015Review
- Limitations of Aneuploidy and Anomaly Detection in the Obese Patient.Journal of clinical medicine · 2014Review
- Prevalence estimates of gestational diabetes mellitus in the United States, Pregnancy Risk Assessment Monitoring System (PRAMS), 2007-2010.Preventing chronic disease · 2014 · on this mapArticle
- Maternal high-fat diet induces hyperproliferation and alters Pten/Akt signaling in prostates of offspring.Scientific reports · 2013Article
- Family-based association study between SLC2A1, HK1, and LEPR polymorphisms with myelomeningocele in Chile.Reproductive sciences (Thousand Oaks, Calif.) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The incidence of obesity in pregnancy has increased over the past 2 decades, with nearly 50% of U.S. women aged 15-49 years classified as overweight or obese. Obesity (independent of diabetes) among gravidae poses unique risks that extend toward the fetus, with several large population-based analyses demonstrating independent increased risks for fetal malformations including neural tube defects, cardiac anomalies, and orofacial clefts, as well as stillbirth and macrosomia. Unfortunately, several lines of evidence also suggest that the quality of the prenatal fetal anatomic survey and certain aspects of prenatal diagnostic screening programs are significantly limited. The net effect is that among obese gravidae, the increased risk of fetal anomalies is further offset by a concomitant diminished ability to sonographically detect such malformations in the prenatal interval. The purpose of this summary review is to systematically examine the evidence suggesting an increased risk of fetal malformations in obese gravidae, the contributing role of diabetes, and the limitations of prenatal diagnostic and sonographic screening among this at-risk population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.