ArticleDiagnostic pathology2012
Oncogenic reg IV is a novel prognostic marker for glioma patient survival.
Article in Diagnostic pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Regenerating gene 4 promotes chemoresistance of colorectal cancer by affecting lipid droplet synthesis and assembly.World journal of gastroenterology · 2023Pooled it
- Herbal medicine,Frontiers in pharmacology · 2023Pooled it
- Pancreatic Stone Protein as a Versatile Biomarker: Current Evidence and Clinical Applications.Diseases (Basel, Switzerland) · 2025Review
- Upregulation of REG IV gene in human intestinal epithelial cells by lipopolysaccharide via downregulation of microRNA-24.Journal of cellular and molecular medicine · 2022Article
- REG4 promotes the proliferation and anti-apoptosis of cancer.Frontiers in cell and developmental biology · 2022Review
- Okamoto model for necrosis and its expansions, CD38-cyclic ADP-ribose signal system for intracellular CaProceedings of the Japan Academy. Series B, Physical and biological sciences · 2021Article
- Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma.Biological research · 2017Article
- The role of the REG4 gene and its encoding product in ovarian epithelial carcinoma.BMC cancer · 2015Article
- MicroRNA-21 expression is associated with overall survival in patients with glioma.Diagnostic pathology · 2013Article
- RTEL1 tagging SNPs and haplotypes were associated with glioma development.Diagnostic pathology · 2013Article
- Sudden, unexpected death due to glioblastoma: report of three fatal cases and review of the literature.Diagnostic pathology · 2013Review
- GATA4 and DcR1 methylation in glioblastomas.Diagnostic pathology · 2013Article
- Correlation of microRNA-372 upregulation with poor prognosis in human glioma.Diagnostic pathology · 2013Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aberrant expression of regenerating islet-derived family member, 4 (Reg IV) has been found in various human cancers. However, the roles of Reg IV gene and its encoding product in human glioma have not been clearly understood. Therefore, the aim of this study was to investigate the clinicopathological significance of Reg IV expression in glioma.
methodsReg IV mRNA and protein expression in human gliomas and non-neoplastic brain tissues were respectively detected by real-time quantitative RT-PCR assay, Western blot, and immunohistochemistry. The association of Reg IV immunostaining with clinicopathological factors and prognosis of glioma patients was also statistically analyzed.
resultsReg IV mRNA and protein expression levels in glioma tissues were both significantly higher than those in the corresponding non-neoplastic brain tissues (both P < 0.001). Additionally, the increased Reg IV immunostaining in glioma tissues was significantly associated with advanced pathological grade (P = 0.008). Reg IV protein up-regulation was also significantly correlated with low Karnofsky performance score (KPS) (P = 0.02). Moreover, the overall survival of patients with high Reg IV protein expression was dramatically shorter than those with low Reg IV protein expression (P < 0.001). Multivariate Cox regression analysis further confirmed that Reg IV expression was an independent prognostic factor for patients with gliomas (P = 0.008).
conclusionsThese convinced evidences suggest for the first time that Reg IV might accelerate disease progression and act as a candidate prognostic marker for gliomas. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/2145344361720706.
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