ArticleMolecular & cellular proteomics : MCP2012
Bacterial responses to a simulated colon tumor microenvironment.
Article in Molecular & cellular proteomics : MCP, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Factors underlying the association betweenGut microbiome (Cambridge, England) · 2024Review
- Association of theOpen forum infectious diseases · 2023Article
- Global proteomic identifies multiple cancer-related signaling pathways altered by a gut pathobiont associated with colorectal cancer.Scientific reports · 2023Article
- Transcriptome profiling of human col\onic cells exposed to the gut pathobiont Streptococcus gallolyticus subsp. gallolyticus.PloS one · 2023Article
- Differential Mucosal Microbiome Profiles across Stages of Human Colorectal Cancer.Life (Basel, Switzerland) · 2021Article
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- Article
- Metabolic models predict bacterial passengers in colorectal cancer.Cancer & metabolism · 2020Article
- Gut Bacteria and their Metabolites: Which One Is the Defendant for Colorectal Cancer?Microorganisms · 2019Review
- Antibody Responses toCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- Colorectal cancer specific conditions promoteProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Significance ofFrontiers in microbiology · 2018Review
- The Road to Infection: Host-Microbe Interactions Defining the Pathogenicity ofFrontiers in microbiology · 2018Review
- Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development.PLoS pathogens · 2017Article
- The Pil3 pilus of Streptococcus gallolyticus binds to intestinal mucins and to fibrinogen.Gut microbes · 2016Article
- Mucosal adherent bacterial dysbiosis in patients with colorectal adenomas.Scientific reports · 2016Article
- Pharmacomicrobiomics: the impact of human microbiome variations on systems pharmacology and personalized therapeutics.Omics : a journal of integrative biology · 2014Review
- Altered tissue metabolites correlate with microbial dysbiosis in colorectal adenomas.Journal of proteome research · 2014Article
- Microbes, microbiota, and colon cancer.Cell host & microbe · 2014Review
- Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the few bacteria that have been consistently linked to colorectal cancer (CRC) is the opportunistic pathogen Streptococcus gallolyticus. Infections with this bacterium are generally regarded as an indicator for colonic malignancy, while the carriage rate of this bacterium in the healthy large intestine is relatively low. We speculated that the physiological changes accompanying the development of CRC might favor the colonization of this bacterium. To investigate whether colon tumor cells can support the survival of S. gallolyticus, this bacterium was grown in spent medium of malignant colonocytes to simulate the altered metabolic conditions in the CRC microenvironment. These in vitro simulations indicated that S. gallolyticus had a significant growth advantage in these spent media, which was not observed for other intestinal bacteria. Under these conditions, bacterial responses were profiled by proteome analysis and metabolic shifts were analyzed by (1)H-NMR-spectroscopy. In silico pathway analysis of the differentially expressed proteins and metabolite analysis indicated that this advantage resulted from the increased utilization of glucose, glucose derivates, and alanine. Together, these data suggest that tumor cell metabolites facilitate the survival of S. gallolyticus, favoring its local outgrowth and providing a possible explanation for the specific association of S. gallolyticus with colonic malignancy.
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